L9143
リポポリサッカリド Pseudomonas aeruginosa10（緑膿菌）由来
purified by phenol extraction
別名:
LPS
製品名
リポポリサッカリド Pseudomonas aeruginosa10（緑膿菌）由来, purified by phenol extraction
biological source
Pseudomonas aeruginosa (10)
form
lyophilized powder
purified by
phenol extraction
impurities
<3% Protein (Lowry)
color
white to faint yellow
solubility
water: 4.90-5.10 mg/mL, faintly hazy to hazy, colorless to faintly yellow
shipped in
ambient
storage temp.
2-8°C
Quality Level
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関連するカテゴリー
Biochem/physiol Actions
リポ多糖類（LPS）は膜の外層に局在しており、非カプセル化菌株では細胞表面に露出しています。LPS は外膜の完全性に寄与し、胆汁酸塩および親油性抗生物質の作用に対して細胞を保護します。
General description
この製品は緑膿菌血清型 10.22 からフェノール抽出したものです。ソースとなる菌株は ATCC 27316 です。
Application
リポ多糖類（LPS）はグラム陰性細菌の細胞壁に特徴的な成分です。LPS とその脂質A成分は、一般的な病原体関連分子パターン（PAMP）を認識する Toll 様受容体タンパク質ファミリーに属する Toll 様受容体 4（TLR4）を介して自然免疫系の細胞を刺激します。
Preparation Note
この製品は水（5 mg/mL）または細胞培養液（1 mg/mL）に可溶で、かすんだ、淡黄色の溶液を与えます。さらに濃度をあげるには、さらに濁りますが、生理食塩水中でボルテックスにかけ 70～80°Cに温めることで 20 mg/mL の溶液が得られます。リポ多糖類はいずれの溶媒中でもミセルを生成する分子です。水およびリン酸緩衝生理食塩水中ではもやっとした溶液となります。有機溶媒ではきれいな溶液とはなりません。メタノールでは浮遊物を伴う濁った懸濁液となりますが、水では均質でかすんだ溶液となります。
保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Keiko Yamauchi et al.
International journal of biological sciences, 5(7), 667-678 (2009-11-07)
Azithromycin (AZM), a 15-member macrolide antibiotic, possesses anti-inflammatory activity. Macrophages are important in innate and acquired immunity, and produce pro-inflammatory cytokines such as interleukin (IL)-12, which are composed of subunit p40 and p35. The key function of IL-12 is the
Khaled Taha-Abdelaziz et al.
Veterinary research, 47, 44-44 (2016-03-19)
β-defensins are an important element of the mucosal innate immune response against bacterial pathogens. Tracheal antimicrobial peptide (TAP) has microbicidal activity against the bacteria that cause bovine respiratory disease, and its expression in tracheal epithelial cells is upregulated by bacterial
Sudarshan Singh Rathore et al.
Scientific reports, 7(1), 15400-15400 (2017-11-15)
Cryptococcus neoformans infection is quite complex with both host-pathogen interaction and host immune profile determining disease progress and therapeutic outcome. Hence in the present study, the potential utility of (E)-5-benzylidenedihydrofuran-2(3 H)-one (compound-6) was explored as an effective anticryptococcal compound with immunomodulatory
Lesley Berghuis et al.
Veterinary research, 45, 105-105 (2014-10-12)
Bovine respiratory disease is a complex of bacterial and viral infections of economic and welfare importance to the beef industry. Although tracheal antimicrobial peptide (TAP) has microbicidal activity against bacterial pathogens causing bovine respiratory disease, risk factors for bovine respiratory
Kettani-Halabi Mohamed et al.
Plant signaling & behavior, 10(3), e1000160-e1000160 (2015-03-12)
Lipopolysaccharides (LPS) are a component of the outer cell surface of almost all Gram-negative bacteria and play an essential role for bacterial growth and survival. Lipopolysaccharides represent typical microbe-associated molecular pattern (MAMP) molecules and have been reported to induce defense-related
資料
Explore the structure, function, and diverse applications of Lipopolysaccharides. Discover their role in bacteria, serological specificity, and research potential.
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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