M0763
メトクロプラミド 塩酸塩
D2 antagonist, solid
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この商品について
実験式（ヒル表記法）:
C14H22ClN3O2 · HCl
CAS番号:
分子量:
336.26
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
230-634-5
MDL number:
製品名
メトクロプラミド 塩酸塩, solid
InChI
1S/C14H22ClN3O2.ClH/c1-4-18(5-2)7-6-17-14(19)10-8-11(15)12(16)9-13(10)20-3;/h8-9H,4-7,16H2,1-3H3,(H,17,19);1H
InChI key
RVFUNJWWXKCWNS-UHFFFAOYSA-N
SMILES string
Cl.CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OC
form
solid
color
white
solubility
H2O: soluble
originator
Baxter
Quality Level
Gene Information
human ... DRD2(1813), HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242), HTR4(3360)
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Biochem/physiol Actions
D2 antagonist; 5-HT3 antagonist; antipsychotic; anti-emetic.
Features and Benefits
This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Baxter. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
保管分類
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
R W Pero et al.
Molecular and cellular biochemistry, 193(1-2), 119-125 (1999-05-20)
Our laboratory has concentrated on the possible regulation the benzamides and nicotinamides may have on the processes of DNA repair and apoptosis. Recent reports have suggested that both apoptosis and inflammation are regulated by the transcription factor NF-kappaB. We have
B Y De Winter et al.
Gut, 45(5), 713-718 (1999-10-13)
The effects of different prokinetic agents, the motilide erythromycin and the substituted benzamides metoclopramide and cisapride, were investigated in a rat model of postoperative ileus. These effects were compared with that of granisetron, a 5-hydroxytryptamine (5-HT(3)) receptor antagonist, and a
M K Ladola et al.
Indian journal of pharmaceutical sciences, 76(5), 423-429 (2014-11-27)
In the present investigation, a novel multifunctional co-processed superdisintegrants consisting of crospovidone and Kyron T-314 were fabricated by solvent evaporation method to develop melt-in-mouth tablets of metoclopramide hydrochloride with a view to enhance patient compliance by direct compression method. The
Diogo F Antunes et al.
Molecular and cellular endocrinology, 550, 111649-111649 (2022-04-19)
Dopamine is part of the reward system triggering the social decision-making network in the brain. It has hence great potential importance in the regulation of social behaviour, but its significance in the control of behaviour in highly social animals is
Mark L Kovler et al.
Science translational medicine, 13(612), eabg3459-eabg3459 (2021-09-23)
Necrotizing enterocolitis (NEC) is a devastating disease of premature infants, whose pathogenesis remains incompletely understood, although activation of the Gram-negative bacterial receptor Toll-like receptor 4 (TLR4) on the intestinal epithelium plays a critical role. Patients with NEC typically display gastrointestinal
資料
DISCOVER Bioactive Small Molecules for Neuroscience
関連コンテンツ
神経科学分野における低分子生理活性物質の創薬研究
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