M2518
メナジオン重亜硫酸ナトリウム
BioReagent, suitable for cell culture, ≥95% (TLC)
別名:
2-メチル-1,4-ナフトキノン重亜硫酸ナトリウム
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この商品について
実験式（ヒル表記法）:
C11H9NaO5S
CAS番号:
分子量:
276.24
NACRES:
NA.75
PubChem Substance ID:
UNSPSC Code:
12352205
EC Number:
204-987-0
MDL number:
Assay:
≥95% (TLC)
Form:
powder
form
powder
InChI key
XDPFHGWVCTXHDX-UHFFFAOYSA-M
InChI
1S/C11H10O5S.Na/c1-11(17(14,15)16)6-9(12)7-4-2-3-5-8(7)10(11)13;/h2-5H,6H2,1H3,(H,14,15,16);/q;+1/p-1
SMILES string
[Na+].CC1(CC(=O)c2ccccc2C1=O)S([O-])(=O)=O
biological source
synthetic (organic)
product line
BioReagent
assay
≥95% (TLC)
mol wt
Mw 276.24 g/mol
technique(s)
cell culture | mammalian: suitable, cell culture | plant: suitable
color
white to off-white
solubility
water: soluble 50 mg/mL, clear, colorless to light yellow
storage temp.
−20°C
Quality Level
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Other Notes
水溶性ビタミンK3。
Application
Menadione sodium bisulfite has been used:
- as a free radical inducer to study its effects on oxidative stress in sunflower seedlings
- as a positive control to produce mitochondrial O2 during the measurement of O2 in human proximal tubular cell lines
- as a redox-cycling mitochondrial pro-oxidant to study its effects on protein kinase B (AKT) and mechanistic target of rapamycin (mTOR) signaling in cardiac cells
Biochem/physiol Actions
Menadione sodium bisulfite (MSB) is a derivative of vitamin K3 and has been studied in the treatment of hemorrhagic diseases like hypoprothrombinemia and neonatal hemorrhage, caused due to vitamin K3 deficiency. It is also considered a nutritional supplement for animals. MSB shows anticancer effects. It also protects plants from biotic and abiotic stress.
Disclaimer
The product is not intended for use as a biocide under global biocide regulations, including but not limited to US EPA′s Federal Insecticide Fungicide and Rodenticide Act, European Biocidal Products Regulation, Canada’s Pest Management Regulatory Agency, Turkey’s Biocidal Products Regulation, Korea’s Consumer Chemical Products and Biocide Safety Management Act (K-BPR) and others.
signalword
Warning
hcodes
Hazard Classifications
Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2
保管分類
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
M2518-500G: + M2518-BULK: + M2518-VAR: + M2518-100G:
jan
Y Sanada et al.
Free radical research, 48(8), 919-928 (2014-05-29)
Human oxidation resistance 1 (OXR1) functions in protection against oxidative damage and its homologs are highly conserved in eukaryotes examined so far, but its function still remains uncertain. In this study, we identified a homolog (LMD-3) of human OXR1 in
Kenneth W Olsen et al.
Molecular vision, 17, 270-278 (2011-02-02)
The crystalline lens is a unique cellular organ that performs metabolic processes while maintaining transparency for optical functionality. Mitochondria play a role in providing cells with aerobic respiration necessary for these metabolic processes. Using menadione, a mitochondria-specific inhibitor of the
Dmytro V Gospodaryov et al.
Biochimica et biophysica acta, 1837(11), 1861-1869 (2014-08-16)
An assembled cDNA coding for the putative single-subunit NADH dehydrogenase (NDX) of Ciona intestinalis was introduced into Drosophila melanogaster. The encoded protein was found to localize to mitochondria and to confer rotenone-insensitive substrate oxidation in organello. Transgenic flies exhibited increased
Irina Baran et al.
Cell biochemistry and biophysics, 58(3), 169-179 (2010-08-11)
Menadione (MD) is an effective cytotoxic drug able to produce intracellularly large amounts of superoxide anion. Quercetin (QC), a widely distributed bioflavonoid, can exert both antioxidant and pro-oxidant effects and is known to specifically inhibit cell proliferation and induce apoptosis
Tomokazu Souma et al.
Journal of the American Society of Nephrology : JASN, 22(4), 635-648 (2011-03-05)
A highly acidic environment surrounds proximal tubular cells as a result of their reabsorption of HCO(3)(-). It is unclear whether this luminal acidity affects proteinuria-induced progression of tubular cell damage. Here, we investigated the contribution of luminal acidity to superoxide
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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