M5005
塩化マンガン(II) 四水和物
BioReagent, suitable for insect cell culture
別名:
Manganese chloride hydrate, Manganese chloride tetrahydrate, MnCl2.4H2O
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この商品について
化学式:
MnCl2 · 4H2O
CAS番号:
分子量:
197.91
NACRES:
NA.28
PubChem Substance ID:
UNSPSC Code:
12352207
EC Number:
231-869-6
MDL number:
製品名
塩化マンガン(II) 四水和物, BioReagent, suitable for insect cell culture
InChI key
CNFDGXZLMLFIJV-UHFFFAOYSA-L
InChI
1S/2ClH.Mn.4H2O/h2*1H;;4*1H2/q;;+2;;;;/p-2
SMILES string
Cl[Mn]Cl.[H]O[H].[H]O[H].[H]O[H].[H]O[H]
product line
BioReagent
assay
≥99% (by AgNO3, titration)
technique(s)
cell culture | insect: suitable
mp
58 °C (lit.)
Quality Level
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関連するカテゴリー
Application
Manganese(II) chloride tetrahydrate has been used:
- as trace element in the fungal complete medium
- as a supplement in the culture medium for cochlear organotypic culture
- to determine its in vivo antiviral activity against herpes simplex virus-1 (HSV-1), vesicular stomatitis virus (VSV) and vaccinia virus in mice
Biochem/physiol Actions
Manganese is an essential and one of the abundant metal in the tissues of mammals. It plays a key role in the physiological process like development, neuronal function, immune regulation, reproduction, and antioxidant defences. It functions as a cofactor and regulates the activity of the enzymes like oxido-reductases, isomerases, transferases, ligases, lyases and hydrolases It is involved in the innate immunity against viruses.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Eye Dam. 1 - STOT RE 2
target_organs
Brain
保管分類
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
wgk
WGK 2
flash_point_f
does not flash
flash_point_c
does not flash
ppe
dust mask type N95 (US), Eyeshields, Gloves
Salidroside protects inner ear hair cells and spiral ganglion neurons from manganese exposure by regulating ROS levels and inhibiting Apoptosis
Ding X, et al.
Toxicology Letters, 310, 51-60 (2019)
manganese Increases the Sensitivity of the cgas-sting Pathway for Double-stranded Dna and Is Required for the Host Defense against Dna Viruses.
Wang C, et al.
Immunity, 48(4), 675-687 (2018)
Weilong Wang et al.
Toxicology letters, 279, 77-86 (2017-08-06)
Manganese (Mn) is an indispensable cofactor for many enzymes and a basic factor for many reproductive and metabolic pathways. However, exposure to high concentrations of Mn can result in deleterious effects on the central nervous system and peripheral nerves, including
Agrobacterium-mediated transformation of the filamentous fungus Aspergillus awamori.
Michielse CB, et al.
Nature Protocols, 3(10), 1671-1671 (2008)
Xuerui Ding et al.
Toxicology letters, 310, 51-60 (2019-04-17)
Manganese (Mn) is an essential cofactor for many enzymes and thus plays an important role in normal growth and development. However, persistent exposure to high Mn concentrations can result in deleterious effects on not only the central nervous system but
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