M6444
Anti-Mitofusin 2 antibody produced in rabbit
~1 mg/mL, affinity isolated antibody, buffered aqueous solution
別名:
Anti-CMT2A, Anti-CMT2A2, Anti-CPRP1, Anti-KIAA0214, Anti-MARF, Anti-Mfn2
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この商品について
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IP, WB CL
Species reactivity:
human, mouse, rat
Citations:
23
Technique(s):
immunoprecipitation (IP): 5-10 μg using HeLa human epitheloid carcinoma cell lysate, western blot (chemiluminescent): 0.5-1 μg/mL using extract of mouse and rat brain mitochondria
Uniprot accession no.:
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~86 kDa
species reactivity
human, mouse, rat
concentration
~1 mg/mL
technique(s)
immunoprecipitation (IP): 5-10 μg using HeLa human epitheloid carcinoma cell lysate, western blot (chemiluminescent): 0.5-1 μg/mL using extract of mouse and rat brain mitochondria
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... MFN2(9927)
mouse ... Mfn2(170731)
rat ... Mfn2(64476)
Application
Anti-Mitofusin 2 antibody has been used in immunoblotting. It may also be used in immunoprecipitation.
Anti-Mitofusin 2 antibody produced in rabbit has been used for Western blotting.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)
Western Blotting (1 paper)
Biochem/physiol Actions
MFN2 is essential for the maintenance of mitochondrial network and controls mitochondrial metabolism. Mfn2-dependent regulatory mechanism is disturbed in obesity by reduced Mfn2 expression. Mutations in MFN2 cause Charcot Marie-Tooth neuropathy type 2A, a neurological disorder that results from degeneration of axons in peripheral nerves.
Mitofusin-2 (MFN2) plays an important role as a mitochondrial fusion protein and participates in many cell processes. It is mainly involved in regulating metabolic processes in the mitochondria. MFN2 prevents the formation of reactive oxygen species and controls endoplasmic reticulum stress. Mutations in the gene encoding this protein have been linked to diabetes and obesity.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Anti-Mitofusin 2 is produced in rabbit using as immunogen a synthetic peptide corresponding to human mitofusin 2 with an N-terminal added cysteine, conjugated to KLH. Mitofusins (Mfn1 and Mfn2) form homotypic and heterotypic complexes for fusion in mitochondria.
Mitofusin-2 (MFN2) is an outer mitochondrial membrane protein.
Immunogen
synthetic peptide corresponding to amino acid residues 557-576 of human mitofusin 2 with an N-terminal added cysteine, conjugated to KLH. The corresponding sequence differs by one and two amino acids in rat and mouse mitofusin 2, respectively.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
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保管分類
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
M6444-VAR: + M6444-200UL: + M6444-BULK:
jan
Dysregulation of mitochondrial quality control processes contribute to sarcopenia in a mouse model of premature aging
Joseph A M,et al.
Testing, 8(7), e69327-e69327 (2013)
Ashley J Smuder et al.
Free radical biology & medicine, 115, 179-190 (2017-12-05)
Mechanical ventilation (MV) results in the rapid development of ventilator-induced diaphragm dysfunction (VIDD). While the mechanisms responsible for VIDD are not fully understood, recent data reveal that prolonged MV activates autophagy in the diaphragm, which may occur as a result
Mfn2 is critical for brown adipose tissue thermogenic function
Boutant M,et al.
The Embo Journal, 36(11), 1543-1558 (2017)
Kuang-Hueih Chen et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 28(1), 382-394 (2013-10-02)
It has been reported that Mitofusin2 (Mfn2) inhibits cell proliferation when overexpressed. We wanted to study the role of endogenous Mfn2 in cell proliferation, along with the structural features of Mfn2 that influence its mitochondrial localization and control of cell
A-M Joseph et al.
Biogerontology, 15(5), 517-534 (2014-08-12)
Mitochondrial dysfunction in various tissues has been associated with numerous conditions including aging. In testes, aging induces atrophy and a decline in male reproductive function but the involvement of mitochondria is not clear. The purpose of this study was to
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