N151
ニソキセチン 塩酸塩
≥98% (HPLC), Norepinephrine reuptake inhibitor, solid
別名:
(±)-γ-(2-メトキシフェノキシ)-N-メチル-ベンゼンプロパンアミン 塩酸塩, LY-94,939
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この商品について
実験式（ヒル表記法）:
C17H21NO2 · HCl
CAS番号:
分子量:
307.82
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
製品名
ニソキセチン 塩酸塩, solid, ≥98% (HPLC)
SMILES string
Cl[H].CNCCC(Oc1ccccc1OC)c2ccccc2
InChI key
LCEURBZEQJZUPV-UHFFFAOYSA-N
InChI
1S/C17H21NO2.ClH/c1-18-13-12-15(14-8-4-3-5-9-14)20-17-11-7-6-10-16(17)19-2;/h3-11,15,18H,12-13H2,1-2H3;1H
assay
≥98% (HPLC)
form
solid
storage condition
desiccated
color
white to beige
solubility
H2O: 20 mg/mL
ethanol: 50 mg/mL
Quality Level
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Application
Nisoxetine has been used as a norepinephrine transport (NET) blocker in autoradiography studies. It has also been used as a NET blocker to study its effects on perivascular adipose tissue.
Biochem/physiol Actions
Nisoxetine is a selective and potent noradrenaline reuptake inhibitor. It has a high affinity towards the noradrenaline transporter. Nisoxetine possesses antidepressant activity.
Features and Benefits
This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
S M Tejani-Butt
The Journal of pharmacology and experimental therapeutics, 260(1), 427-436 (1992-01-01)
The uptake sites for norepinephrine (NE) in brain have not been studied in much detail, probably due to the absence of an adequate radioligand for labeling these sites. This study describes the binding properties of [3H]nisoxetine to uptake sites for
Ching-I A Wang et al.
Molecular pharmacology, 82(5), 898-909 (2012-08-10)
The human norepinephrine transporter (NET) is implicated in many neurological disorders and is a target of tricyclic antidepressants and nisoxetine (NX). We used molecular docking simulations to guide the identification of residues likely to affect substrate transport and ligand interactions
Dagmar E Ettlinger et al.
Nuclear medicine and biology, 35(4), 475-479 (2008-05-17)
Since the late 1980s, cocaine analogues based on the phenyltropane structure, such as [(11)C]CFT and [(123)I]beta-CIT have been used for the imaging of the dopamine transporter. FE@CIT (fluoropropyl ester) and FP-CIT (N-fluoropropyl derivative) are further analogues. The aim of this
B E Leonard
Neurochemistry international, 4(5), 339-350 (1982-01-01)
An attempt has been made to assess critically the clinical and experimental evidence that implicates a malfunctioning of amine neurotransmitter systems in the aetiology of depression. The evidence available does provide indirect evidence in favour of the biogenic amine theory
Trisha L Vickrey et al.
Analytical chemistry, 81(22), 9306-9313 (2009-10-22)
Drosophila melanogaster, the fruit fly, is a commonly used model organism because of its homology to mammals and facile genetic manipulations. However, the size of the nervous system is very small. We report a method to evoke and detect rapid
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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