P0037
PP242 水和物
≥98% (HPLC), powder
別名:
2-(4-アミノ-1-イソプロピル-1H-ピラゾロ[3,4-d]ピリミジン-3-イル)-1H-インドール-5-オール
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この商品について
実験式（ヒル表記法）:
C16H16N6O · xH2O
CAS番号:
分子量:
308.34 (anhydrous basis)
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
製品名
PP242 水和物, ≥98% (HPLC), powder
InChI
1S/C16H16N6O.H2O/c1-8(2)22-16-13(15(17)18-7-19-16)14(21-22)12-6-9-5-10(23)3-4-11(9)20-12;/h3-8,20,23H,1-2H3,(H2,17,18,19);1H2
SMILES string
O.CC(C)n1nc(-c2cc3cc(O)ccc3[nH]2)c4c(N)ncnc14
InChI key
FMDOLJSFPXFBIL-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
off-white
solubility
DMSO: >10 mg/mL
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
PP242は強力かつ選択的なmTORインヒビターです。
PP242は強力かつ選択的なmTORインヒビターです。PP242はmTORのATPドメインを標的とする初の選択的インヒビターです。
Application
PP242 hydrate has been used:
- as a mammalian target of rapamycin (mTOR) inhibitor to study its effects on rat fibroblast mTOR complex 1 and 2 (mTORC1 & 2) signaling
- as an mTOR inhibitor to treat mouse embryonic fibroblasts (MEF) and cumulus cells (CCs) to study its effects on reactivation of embryonic nucleoli and ribosome biogenesis
- as a target of rapamycin (TOR) kinase inhibitor for the treatment of Arabidopsis to study its effects against Fusarium graminearum infection
Features and Benefits
This compound is featured on the PKB/Akt page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
保管分類
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Min Liu et al.
Biochemical and biophysical research communications, 463(3), 255-261 (2015-05-24)
Activation of quiescent hepatic stellate cells (HSCs) is the central event of liver fibrosis. The translational machinery is an optimized molecular network that affects cellular homoeostasis and diseases, whereas the role of protein translation in HSCs activation and liver fibrosis
TOR signaling downregulation increases resistance to the cereal killer Fusarium graminearum
Aznar N, et al.
Plant signaling & behavior, 13(2), e1414120-e1414120 (2018)
Transient inhibition of rDNA transcription in donor cells improves ribosome biogenesis and preimplantation development of embryos derived from somatic cell nuclear transfer
Liao C, et al.
Faseb Journal, 26(12), 2774-2789 (2020)
Piero Dalle Pezze et al.
Autophagy, 17(5), 1131-1141 (2020-04-23)
During macroautophagy/autophagy, the ULK complex nucleates autophagic precursors, which give rise to autophagosomes. We analyzed, by live imaging and mathematical modeling, the translocation of ATG13 (part of the ULK complex) to the autophagic puncta in starvation-induced autophagy and ivermectin-induced mitophagy.
Jigang Wang et al.
Nature protocols, 12(2), 279-288 (2017-01-13)
At present, several assays that use radioisotope labeling to quantify the degradation of long-lived proteins have been developed to measure autophagic flux. Here, we describe a nonradioactive pulse-chase protocol using L-azidohomoalanine (AHA) labeling to quantify long-lived protein degradation during autophagy.
資料
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