P4670
プロパフェノン 塩酸塩
別名:
1-[2-(2-ヒドロキシ-3-(プロピルアミノ)プロポキシ)フェニル]-3-フェニル-1-プロパノン 塩酸塩
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この商品について
実験式（ヒル表記法）:
C21H27NO3 · HCl
CAS番号:
分子量:
377.90
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
251-867-9
MDL number:
InChI
1S/C21H27NO3.ClH/c1-2-14-22-15-18(23)16-25-21-11-7-6-10-19(21)20(24)13-12-17-8-4-3-5-9-17;/h3-11,18,22-23H,2,12-16H2,1H3;1H
InChI key
XWIHRGFIPXWGEF-UHFFFAOYSA-N
SMILES string
Cl[H].CCCNCC(O)COc1ccccc1C(=O)CCc2ccccc2
form
powder
originator
Abbott
storage temp.
2-8°C
Quality Level
Gene Information
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Biochem/physiol Actions
hKv1.5およびATP感受性K+チャネルをブロックします。クラス1C抗不整脈薬で、βアドレナリン受容体のアンタゴニストでもあります。
Application
Propafenone hydrochloride has been used in the isolation of cardiomyocytes.
Features and Benefits
This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
General description
Propafenone hydrochloride is a calcium antagonist. It functions as a Na+ and K+ channel blocker. It might be used to treat patients with systemic hypertension. Propafenone hydrochloride is associated with bradycardia and bronchospasms. It is metabolized in the liver. Propafenone hydrochloride is used to treat ventricular arrhythmias.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
保管分類
11 - Combustible Solids
wgk
WGK 3
Propafenone blocks ATP-sensitive K+ channels in rabbit atrial and ventricular cardiomyocytes
Christe G, et al.
European Journal of Pharmacology, 373(2-3), 223-232 (1999)
A Seki et al.
British journal of pharmacology, 126(5), 1153-1162 (1999-04-16)
1. The class Ic anti-arrhythmic agent, flecainide is known to inhibit the transient outward K current (Ito) selectively in human atrium. We studied the effects of propafenone, another class Ic antiarrhythmic agent, on K currents in human atrial myocytes using
Rate control vs rhythm control in patients with nonvalvular persistent atrial fibrillation: the results of the Polish How to Treat Chronic Atrial Fibrillation (HOT CAFE) Study
Opolski G, et al.
Chest, 126(2), 476-486 (2004)
The multiple modes of action of propafenone
Dukes ID and Williams EMV
European Heart Journal, 5(2), 115-125 (1984)
Pharmacologic management of arrhythmias
Ganjehei L, et al.
Texas Heart Institute Journal, 38(4), 344-344 (2011)
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