S1014
Streptonigrin
from Streptomyces flocculus, ≥98% (HPLC), powder, apoptosis inducer
別名:
ニグリン, ブルネオマイシン
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この商品について
実験式（ヒル表記法）:
C25H22N4O8
CAS番号:
分子量:
506.46
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
223-501-8
MDL number:
Beilstein/REAXYS Number:
599390
製品名
ストレプトニグリン from Streptomyces flocculus, ≥98%
InChI key
PVYJZLYGTZKPJE-UHFFFAOYSA-N
InChI
1S/C25H22N4O8/c1-9-14(10-6-8-13(35-2)23(36-3)20(10)30)15(26)19(29-17(9)25(33)34)12-7-5-11-18(28-12)22(32)16(27)24(37-4)21(11)31/h5-8,30H,26-27H2,1-4H3,(H,33,34)
SMILES string
COc1ccc(c(O)c1OC)-c2c(C)c(nc(c2N)-c3ccc4C(=O)C(OC)=C(N)C(=O)c4n3)C(O)=O
assay
≥98%
antibiotic activity spectrum
viruses
mode of action
DNA synthesis | interferes
storage temp.
2-8°C
Quality Level
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Biochem/physiol Actions
ストレプトニグリン（SN）は、アミノキノン系抗腫瘍抗生物質です。その抗腫瘍活性には、キサンチン変換酵素による還元的活性化が必要です。NF-κBが関与するメカニズムによりアポトーシスを誘導します。SNによるDNA切断反応と染色体損傷は、存在する金属イオンの性質に影響され、フリーラジカルの生成に依存します。その抗生物質活性は、鉄で活性化されています。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 1 Oral
保管分類
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
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