S2647
スペクチノマイシン 二塩酸塩 五水和物
powder, γ-irradiated
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この商品について
実験式（ヒル表記法）:
C14H24N2O7 · 2HCl · 5H2O
CAS番号:
分子量:
495.35
NACRES:
NA.85
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
244-554-3
MDL number:
製品名
スペクチノマイシン 二塩酸塩 五水和物, powder, γ-irradiated
InChI key
DCHJOVNPPSBWHK-UXXUFHFZSA-N
InChI
1S/C14H24N2O7.2ClH.5H2O/c1-5-4-6(17)14(20)13(21-5)22-12-10(19)7(15-2)9(18)8(16-3)11(12)23-14;;;;;;;/h5,7-13,15-16,18-20H,4H2,1-3H3;2*1H;5*1H2/t5-,7-,8+,9+,10+,11-,12-,13+,14+;;;;;;;/m1......./s1
SMILES string
O.O.O.O.O.Cl.Cl.CN[C@@H]1[C@H](O)[C@H](NC)[C@H]2O[C@]3(O)[C@@H](O[C@H](C)CC3=O)O[C@@H]2[C@H]1O
biological source
synthetic (inorganic)
grade
Molecular Biology
sterility
γ-irradiated
form
powder
potency
≥500 μg per mg
storage condition
(Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.)
color
white to off-white
solubility
H2O: soluble at
antibiotic activity spectrum
Gram-negative bacteria
Gram-positive bacteria
mode of action
protein synthesis | interferes
storage temp.
2-8°C
suitability
nonselective for Escherichia coli
nonselective for coliforms
Quality Level
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Preparation Note
ストック溶液はバイアルに滅菌水(10 mg/mL)を加え調製します。保存期間が数週間の場合は2～8°C、それ以上の場合には-20°Cで保存してください。
Biochem/physiol Actions
作用様式：スペクチノマイシンは、タンパク質合成およびバクテリアの30Sリボソームサブユニットへの結合による伸長を阻害し、ペプチジルtRNAの転位を妨げることによって作用します。
耐性の様式：リボソームタンパク質S5の遺伝子であるrpsEの突然変異がスペクチノマイシンの結合を妨げます。耐性はアミノグリコシド-3'-アデニルトランスフェラーゼ遺伝子（aadA）によってももたらされます。
抗菌スペクトル：スペクチノマイシンがグラム陰性およびグラム陽性菌に対して作用します。
耐性の様式：リボソームタンパク質S5の遺伝子であるrpsEの突然変異がスペクチノマイシンの結合を妨げます。耐性はアミノグリコシド-3'-アデニルトランスフェラーゼ遺伝子（aadA）によってももたらされます。
抗菌スペクトル：スペクチノマイシンがグラム陰性およびグラム陽性菌に対して作用します。
Application
Spectinomycin is an aminocyclitol antibiotic derived from Streptomyces spectabilis. It has been shown to have a wide variety of uses, including treating acute gonorrheal urethritis and cervictis, to mark cell layers to monitor cell fate during leaf development, as a selection marker in plant related transformation systems for plant cells containing the marker gene Spcr, to study respiratory tract infections of cattle caused by Pasteurella multocida and Mannheimia haemolytica, and to generate plants deficient for the plastid-encoded RNA polymerase on MS-agar media. Spectinomycin also has use in amplification of low copy number plasmid carrying replicons. It is recommended for use in cell culture applications at 7.5-20 mg/L.
Disclaimer
Solutions can be stored at 2-8°C for several weeks or at -20°C for more extended periods.
General description
Chemical structure: aminoglycoside
Other Notes
Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.
Packaging
100MG
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
保管分類
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
K Matsumoto et al.
Journal of bacteriology, 180(1), 100-106 (1998-01-09)
The psd gene of Bacillus subtilis Marburg, encoding phosphatidylserine decarboxylase, has been cloned and sequenced. It encodes a polypeptide of 263 amino acid residues (deduced molecular weight of 29,689) and is located just downstream of pss, the structural gene for
Susanna Ricci et al.
Infection and immunity, 70(9), 4968-4976 (2002-08-17)
Ferric uptake regulator (Fur) and Fur-like proteins form an important family of transcriptional regulators in many bacterial species. In this work we have characterized a Fur-like protein, the peroxide regulator PerR, in an M1 serotype of Streptococcus pyogenes. To determine
Praveen Kumar et al.
Journal of separation science, 35(4), 498-504 (2012-01-28)
The effect of mobile-phase constituents (pH and ionic strength) and chromatographic behaviour of ten aminoglycosides (streptomycin, dihydrostreptomycin, spectinomycin, apramycin, paramomycin, kanamycin A, gentamycin C1, gentamycin C2/C2a, gentamycin C1a and neomycin) in the bare silica, amino, amide and zwitterionic phases of
Amber M Hotto et al.
G3 (Bethesda, Md.), 1(7), 559-570 (2012-03-03)
Noncoding RNAs (ncRNA) are widely expressed in both prokaryotes and eukaryotes. Eukaryotic ncRNAs are commonly micro- and small-interfering RNAs (18-25 nt) involved in posttranscriptional gene silencing, whereas prokaryotic ncRNAs vary in size and are involved in various aspects of gene
Marty K Soehnlen et al.
Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc, 23(3), 547-551 (2011-09-13)
Mycoplasma bovis is an important pathogen of cattle, causing mastitis, pneumonia, conjunctivitis, otitis, and arthritis. Currently there are only a few reports of sensitivity levels for M. bovis isolates from the United States. Mycoplasma bovis isolates submitted to the Pennsylvania
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