S8753
ストリキニーネ 塩酸塩
glycine receptor antagonist
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この商品について
実験式（ヒル表記法）:
C21H22N2O2 · HCl
CAS番号:
分子量:
370.87
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352210
EC Number:
215-826-9
MDL number:
製品名
ストリキニーネ 塩酸塩,
InChI key
VLXYTKMPCOQKEM-ZEYGOCRCSA-N
InChI
1S/C21H22N2O2.ClH/c24-18-10-16-19-13-9-17-21(6-7-22(17)11-12(13)5-8-25-16)14-3-1-2-4-15(14)23(18)20(19)21;/h1-5,13,16-17,19-20H,6-11H2;1H/t13-,16-,17-,19-,20-,21+;/m0./s1
SMILES string
Cl.[H][C@@]12CC(=O)N3c4ccccc4[C@]56CCN7CC(=CCO1)[C@]([H])(C[C@@]57[H])[C@]2([H])[C@]36[H]
Quality Level
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Biochem/physiol Actions
けいれん薬です。グリシンレセプタ-のアンタゴニストですが、NMDAレセプタ-には結合しません。
Strychnine is a potent convulsant, which is extracted from Strychnos nux vomica seeds. At high doses, the compound causes convulsions and ultimately death due to respiratory paralysis. Strychnine acts as a respiratory, circulatory and digestive stimulant.
Application
Strychnine hydrochloride has been used as a glycine receptor antagonist in the retina for biophysiological functions. It has also been used to block glutamatergic, GABAergic and glycinergic receptors and gap junctions.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Acute 1 - Aquatic Chronic 1
保管分類
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
Biomarkers in Toxicology null
Y-cell receptive field and collicular projection of parasol ganglion cells in macaque monkey retina.
Joanna D Crook et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 28(44), 11277-11291 (2008-10-31)
The distinctive parasol ganglion cell of the primate retina transmits a transient, spectrally nonopponent signal to the magnocellular layers of the lateral geniculate nucleus. Parasol cells show well-recognized parallels with the alpha-Y cell of other mammals, yet two key alpha-Y
Horizontal cell feedback without cone type-selective inhibition mediates red?green color opponency in midget ganglion cells of the primate retina
Crook JD, et al.
The Journal of Neuroscience, 31(5), 1762-1772 (2011)
Direct activation of the Mauthner cell by electric field pulses drives ultrarapid escape responses
Tabor KM, et al.
Journal of Neurophysiology, 112(4), 834-844 (2014)
Y-cell receptive field and collicular projection of parasol ganglion cells in macaque monkey retina
Crook JD, et al.
The Journal of Neuroscience, 28(44), 11277-11291 (2008)
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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