SAB2700181
Anti-NS3 antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
別名:
Dengue virus 2 Nonstructural protein NS3, Non-structure protein 3
ログインで組織・契約価格をご覧ください。
サイズを選択してください
この商品について
NACRES:
NA.43
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
flow cytometry
immunofluorescence
immunohistochemistry
western blot
immunofluorescence
immunohistochemistry
western blot
Species reactivity:
Dengue virus
Citations:
32
Technique(s):
flow cytometry: suitable
immunofluorescence: suitable
immunohistochemistry: suitable
western blot: 500-3000
immunofluorescence: suitable
immunohistochemistry: suitable
western blot: 500-3000
製品名
Anti-NS3 antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
Dengue virus
technique(s)
flow cytometry: suitable
immunofluorescence: suitable
immunohistochemistry: suitable
western blot: 500-3000
NCBI accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Application
Suggested starting dilutions are as follows: FACS: Assay-dependent dilution, ICC/IF: 1:100-1:2000, IHC: Assay-dependent dilution, IHC-P: Assay-dependent dilution, WB: 1:500-1:3000. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.
Anti-NS3 antibody produced in rabbit has been used in flow cytometry.
Anti-NS3 antibody produced in rabbit has been used in flow cytometry.
Biochem/physiol Actions
Non-structure protein 3 (NS3) along with NS2B play a vital role in proteolytic cleavage of dengue virus (DEN) non-structural proteins. NS3 also acts as a RNA-stimulated nucleoside-triphosphatase (NTPase)/RNA helicase and a 5′-RNA triphosphatase (RTPase).
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
General description
Non-structure protein 3 (NS3), also known as dengue virus type 2 (DEN2), belongs to the Flaviviridae family. NS3 is a multifunctional protein with a molecular mass of about 69 kDa. It contains serine protease domain (NS3-pro) and it needs the hydrophilic domain of NS2B (NS2BH) for activation.
Immunogen
Recombinant protein fragment contain a sequence corresponding to a region within amino acids 354 and 568 of NS3 (Dengue virus 2) according to NP_739587
Physical form
1XPBS, 20% Glycerol (pH7). 0.025% ProClin 300 was added as a preservative.
適切な製品が見つかりませんか。
製品選択ツール.をお試しください
signalword
Warning
hcodes
Hazard Classifications
Aquatic Chronic 3 - Skin Sens. 1
保管分類
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
SAB2700181-100UL:4548173320168 + SAB2700181-100UG:
jan
Both nonstructural proteins NS2B and NS3 are required for the proteolytic processing of dengue virus nonstructural proteins.
Falgout B, et al.
Journal of Virology, 65(5), 2467-2475 (1991)
RIG-I?like Receptor Triggering by Dengue Virus Drives Dendritic Cell Immune Activation and TH1 Differentiation.
Sprokholt JK, et al.
Journal of Immunology, 1602121-1602121 (2017)
RIG-I-like receptor activation by dengue virus drives follicular T helper cell formation and antibody production.
Sprokholt JK, et al.
PLoS Pathogens, 13(11), e1006738-e1006738 (2017)
Modulation of the nucleoside triphosphatase/RNA helicase and 5′-RNA triphosphatase activities of Dengue virus type 2 nonstructural protein 3 (NS3) by interaction with NS5, the RNA-dependent RNA polymerase.
Yon C, et al.
The Journal of Biological Chemistry (2005)
Joris K Sprokholt et al.
PLoS pathogens, 13(11), e1006738-e1006738 (2017-12-01)
Follicular T helper cells (TFH) are fundamental in orchestrating effective antibody-mediated responses critical for immunity against viral infections and effective vaccines. However, it is unclear how virus infection leads to TFH induction. We here show that dengue virus (DENV) infection
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
製品に関するお問い合わせはこちら（テクニカルサービス）