SAB3500383
Anti-CXCR4 antibody produced in rabbit
IgG fraction of antiserum, buffered aqueous solution
別名:
Anti-CXCR4
製品名
Anti-CXCR4 antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution
biological source
rabbit
conjugate
unconjugated
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
mouse, human
technique(s)
flow cytometry: suitable
immunocytochemistry: suitable
immunofluorescence: suitable
immunoprecipitation (IP): suitable
indirect ELISA: suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... CXCR4(7852)
関連するカテゴリー
Application
Anti-CXCR4 antibody produced in rabbit has been used in western blot analysis and indirect ELISA.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)
Western Blotting (1 paper)
Biochem/physiol Actions
C-X-C motif chemokine receptor 4 (CXCR4) is specific for stromal cell-derived factor-1. It plays a vital role in regulation of immune response in various immune cell types. CXCR4 interacts with CD4 (cluster of differentiation 4) and permits human immunodeficiency virus type 1 (HIV-1) entry and infection in to the cells. Polymorphism in the gene is associated with the development of Juvenile idiopathic arthritis (JIA). In addition, mutation in the gene increases the risk of susceptibility to cardiovascular diseases (CVDs).
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
General description
C-X-C motif chemokine receptor 4 (CXCR4) is encoded by the gene mapped to human chromosome 2q22.1. The gene codes for a protein with seven transmembrane regions. The encoded protein is expressed on the surface of T-cells, B-cells, monocytes, neutrophils and dendritic cells.
Immunogen
CXCR4 antibody was raised against a peptide corresponding to amino acids near the amino terminus of human CXCR4.
Other Notes
The action of this antibody can be blocked using blocking peptide SBP3500383.
Physical form
Supplied in PBS with 0.02% sodium azide.
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保管分類
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ABT-888 and quinacrine induced apoptosis in metastatic breast cancer stem cells by inhibiting base excision repair via adenomatous polyposis coli.
Siddharth S, et al.
DNA Repair, 45, 44-55 (2016)
Genetic variation of CXCR4 and risk of coronary artery disease: epidemiological study and functional validation of CRISPR/Cas9 system.
Runmin G, et al.
Oncotarget, 9(18), 14077?14083-14077?14083 (2018)
Withaferin A targeting both cancer stem cells and metastatic cancer stem cells in the UP-LN1 carcinoma cell model.
T Lai-Lei, et al.
Journal of Cancer Metastasis and Treatment, 2(1), 29-40 (2016)
CD4-independent infection by HIV-2 is mediated by fusin/CXCR4.
Endres M J, et al.
Cell, 87(4), 745-756 (1996)
Variants in CXCR4 associate with juvenile idiopathic arthritis susceptibility.
Finkel T H, et al.
BMC Medical Genetics, 17(1), 24-24 (2016)
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