SAB4300125

Anti-phospho-NFKBIA (pSer³²/pSer³⁶) antibody produced in rabbit

Name: Anti-phospho-NFKBIA (pSer<SUP>32</SUP>/pSer<SUP>36</SUP>) antibody produced in rabbit
Brand: SIGMA

affinity isolated antibody

別名:

Anti-IKBA antibody produced in rabbit, Anti-MAD-3 antibody produced in rabbit, Anti-NFKBI antibody produced in rabbit, Anti-nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha antibody produced in rabbit

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この商品について

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD01633603

Conjugate:

unconjugated

Clone:

polyclonal

Application:

IF, IHC (p), WB

Citations:

主要文書

すべての文書を表示

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biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

~39 kDa

species reactivity

human, mouse

concentration

1 mg/mL

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100, indirect immunofluorescence: 1:100-1:200, western blot: 1:500-1:1000

isotype

IgG

immunogen sequence

(H-D-SP-G-L-D-SP-M-K)

NCBI accession no.

NP_065390.1

UniProt accession no.

P25963

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pSer32/pSer36)

Quality Level

100

Gene Information

human ... NFKBIA(4792)

General description

Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to tranlocate to the nucleus and activate transcription.

Immunogen

Peptide sequence around phosphorylation site of serine 32/36 (H-D-S(p)-G-L-D-S(p) -M-K), according to the protein NFKBIA.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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保管分類

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

適用法令

試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。

SAB4300125-100UG:

jan

最新バージョンのいずれかを選択してください：

試験成績書（COA）

Lot/Batch Number

871511152

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COAを検索

以前この製品を購入いただいたことがある場合

文書ライブラリで、最近購入した製品の文書を検索できます。

文書ライブラリにアクセスする

Nuclear Translocation of RELB Is Increased in Diseased Human Liver and Promotes Ductular Reaction and Biliary Fibrosis in Mice.

Christin Elßner et al.

Gastroenterology, 156(4), 1190-1205 (2018-11-18)

Cholangiocyte proliferation and ductular reaction contribute to the onset and progression of liver diseases. Little is known about the role of the transcription factor nuclear factor-κB (NF-κB) in this process. We investigated the activities of the RELB proto-oncogene NF-κB subunit

Activation of TNF-α/NF-κB axis enhances CRL4BDCAF11 E3 ligase activity and regulates cell cycle progression in human osteosarcoma cells.

Caiguo Zhang et al.

Molecular oncology, 12(4), 476-494 (2018-01-30)

Cullin 4B, a member of the Cullins, which serve as scaffolds to facilitate the assembly of E3 ligase complexes, is aberrantly expressed in many cancers, including osteosarcoma. Recently, we observed that CUL4B forms the CRL4BDCAF11 E3 ligase, which specifically ubiquitinates

Activated kinase screening identifies the IKBKE oncogene as a positive regulator of autophagy.

Margherita Leonardi et al.

Autophagy, 15(2), 312-326 (2018-10-06)

Macroautophagy/autophagy is one of the major responses to stress in eukaryotic cells and is implicated in several pathological conditions such as infections, neurodegenerative diseases and cancer. Interestingly, cancer cells take full advantage of autophagy both to support tumor growth in

ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.

製品に関するお問い合わせはこちら（テクニカルサービス）

Anti-phospho-NFKBIA (pSer32/pSer36) antibody produced in rabbit

affinity isolated antibody

サイズを選択してください

この商品について

主要文書

特性

biological source

conjugate

antibody form

antibody product type

clone

form

mol wt

species reactivity

concentration

technique(s)

isotype

immunogen sequence

NCBI accession no.

UniProt accession no.

shipped in

storage temp.

target post-translational modification

Quality Level

Gene Information

関連するカテゴリー

詳細

General description

Immunogen

Features and Benefits

Physical form

Disclaimer

安全性情報

保管分類

wgk

flash_point_f

flash_point_c

適用法令

SAB4300125-100UG:

資料

試験成績書（COA）

以前この製品を購入いただいたことがある場合

参考文献

テクニカルサービス

Anti-phospho-NFKBIA (pSer³²/pSer³⁶) antibody produced in rabbit