SAB4300352
Anti-EGFR (Ab-1070) antibody produced in rabbit
affinity isolated antibody
別名:
Anti-ERBB antibody produced in rabbit, Anti-ERBB1 antibody produced in rabbit, Anti-HER1 antibody produced in rabbit, Anti-PIG61 antibody produced in rabbit, Anti-epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) antibody produced in rabbit
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この商品について
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IF, IHC (p), WB
Species reactivity:
human
Citations:
31
Technique(s):
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100, indirect immunofluorescence: 1:100-1:200, western blot: 1:500-1:1000
Uniprot accession no.:
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
~175 kDa
species reactivity
human
concentration
1 mg/mL
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100, indirect immunofluorescence: 1:100-1:200, western blot: 1:500-1:1000
isotype
IgG
immunogen sequence
(R-Y-S-S-D)
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... EGFR(1956)
Application
Anti-EGFR (Ab-1070) antibody has been used in immunohistochemistry.
Biochem/physiol Actions
EGFR (epidermal growth factor receptor) plays an important role in ligand binding, dimerization and autophosphorylation. It also plays an important role in several procarcinogenic cancers like gastric cancer. It controls various functions of epithelial cell. It modulates the actions in bacterial infection and is associated with the initiation of macrophage.
Upon activation by ligands, epidermal growth factor receptor (EGFR, ErbB1) initiates a signaling cascade which includes dimerization and internalization, tyrosine phosphorylation, DNA synthesis of target genes, and, ultimately, cell proliferation. EGFR signaling plays a role in the growth and differentiation of normal cells, but elevated EGFR activity is correlated with the development and pathogenesis of certain cancers.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
General description
EGFR (epidermal growth factor receptor) belongs to the ErbB family of receptor tyrosine kinases. It is also known as ErbB1/HER1 (human epidermal growth factor receptor). It is located on chromosome 7p11.2. It has a large extracellular ligand-binding domain, a single transmembrane segment, an intracellular juxtamembrane segment, a tyrosine kinase domain and a carboxy-terminal tail.
Epidermal growth factor receptor (EGFR, ErbB1) is a transmembrane protein that exerts tyrosine kinase activity upon ligand induced activation. EGFR can be activated by binding EGF or at least six other structurally related protein ligands, including transforming growth factor α (TGFα), heparin-binding EGF-like growth factor (HB-EGF), betacellulin (BTC), amphiregulin, epiregulin and epigen. The gene encoding it is localized on human chromosome 7p11.2.
Receptor for EGF, but also for other members of the EGF family, as TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30 and vaccinia virus growth factor. Is involved in the control of cell growth and differentiation.
Immunogen
Peptide sequence around aa. 1068-1072 (R-Y-S-S-D), according to the protein EGFR.
Physical form
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
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保管分類
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
SAB4300352-100UG:
jan
EGFR regulates macrophage activation and function in bacterial infection
Hardbower DM, et al.
The Journal of Clinical Investigation (2016)
Synthesis and biochemical characterization of EGF receptor in a water-soluble membrane model system
Scharadin TM, et al.
PLoS ONE (2017)
A chromosomal region 7p11.2 transcript map: its development and application to the study of EGFR amplicons in glioblastoma
Eley GD, et al.
Neuro-Oncology (2002)
POPDC1 is suppressed in human breast cancer tissues and is negatively regulated by EGFR in breast cancer cell lines
Amunjela JN and Tucker SJ
Cancer Letters (2017)
Terence Tieu et al.
Biomaterials science, 9(1), 133-147 (2020-11-03)
Targeted delivery of chemotherapeutics to cancer cells has the potential to yield high drug concentrations in cancer cells while minimizing any unwanted side effects. However, the development of multidrug resistance in cancer cells may impede the accumulation of chemotherapy drugs
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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