SML1109
KU-55933
≥98% (HPLC), Ataxia telangiectasia (A-T) mutated (ATM) kinase inhibitor, powder
別名:
2-（4-モルフォリニル）-6-（1-チアントレニル）-4H-ピラン-4-オン, 2-（モルフォリン-4-イル）-6-（チアントレン-1-イル）-4H-ピラン-4-オン
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この商品について
実験式（ヒル表記法）:
C21H17NO3S2
CAS番号:
分子量:
395.49
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
製品名
KU-55933, ≥98% (HPLC)
SMILES string
O=C1C=C(OC(=C1)c2cccc3Sc4ccccc4Sc23)N5CCOCC5
InChI
1S/C21H17NO3S2/c23-14-12-16(25-20(13-14)22-8-10-24-11-9-22)15-4-3-7-19-21(15)27-18-6-2-1-5-17(18)26-19/h1-7,12-13H,8-11H2
InChI key
XRKYMMUGXMWDAO-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
DMSO: 10 mg/mL, clear
storage temp.
−20°C
Quality Level
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Application
KU-55933 は毛細血管拡張性運動失調変異（Atm）阻害剤として用いられています。
Biochem/physiol Actions
KU-55933 は非常に強力で特異的な毛細血管拡張性運動失調（A-T）突然変異型（ATM）キナーゼ阻害剤です。
KU-55933 は非常に強力で特異的な毛細血管拡張性運動失調（A-T）突然変異型（ATM）キナーゼ（IC50 = 13 nM）阻害剤です。KU-22933 の処理は癌細胞の電離放射線や細胞毒性薬への感受性を高めます。化合物 KU-22933 は ATM の媒介する p53、gH2AX、NBS1 および SMC1 のリン酸化反応をブロックします。
保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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