SML2195
AZD6482
≥98% (HPLC)
別名:
(-) 2-[1-(7-methyl-2-(morpholin-4-yl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl)ethylamino]benzoic acid, 2-[[(1R)-1-[7-Methyl-2-(4-morpholinyl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl]ethyl]amino]-benzoic acid, AZD 6482
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この商品について
実験式（ヒル表記法）:
C22H24N4O4
CAS番号:
分子量:
408.45
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
−20°C
SMILES string
[n]21c(nc(c[c]2=O)N4CCOCC4)c(cc(c1)C)[C@H](Nc3c(cccc3)C(=O)O)C
InChI
1S/C22H24N4O4/c1-14-11-17(15(2)23-18-6-4-3-5-16(18)22(28)29)21-24-19(12-20(27)26(21)13-14)25-7-9-30-10-8-25/h3-6,11-13,15,23H,7-10H2,1-2H3,(H,28,29)/t15-/m1/s1
InChI key
IRTDIKMSKMREGO-OAHLLOKOSA-N
Biochem/physiol Actions
AZD6482 is an isoform-selective and potent ATP competitive inhibitor of PI3Kb. AZD6482 produces an antithrombotic effect without an increased bleeding time or blood loss in humans and in dogs.
isoform-selective and potent ATP competitive inhibitor of PI3Kb
保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
SML2195-5MG: + SML2195-25MG: + SML2195-VAR: + SML2195-BULK:
jan
Britta Weigelt et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 19(13), 3533-3544 (2013-05-16)
Endometrioid endometrial cancers (EEC) frequently harbor coexisting mutations in phosphoinositide 3-kinase (PI3K) pathway genes, including PTEN, PIK3CA, PIK3R1, and KRAS. We sought to define the genetic determinants of PI3K pathway inhibitor response in EEC cells, and whether PTEN-mutant EEC cell
S Nylander et al.
Journal of thrombosis and haemostasis : JTH, 10(10), 2127-2136 (2012-08-22)
Based on in vitro and animal data, PI3Kβ is given an important role in platelet adhesion and aggregation but its role in insulin signaling is unclear. To strengthen the PI3Kβ target validation using the novel, short-acting inhibitor AZD6482. AZD6482 is
Chen Zhang et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 37(11), 14831-14839 (2016-09-19)
Breast cancer is one of the leading causes of death for women worldwide. Among various subtypes of breast cancer, human epidermal growth factor receptor 2 (HER2)-positive and phosphatase and tensin homolog (PTEN) loss breast cancer is a cause of great