SML3672
Elvitegravir
≥98% (HPLC)
別名:
6-(3-chloro-2-fluorobenzyl)-1-[(S)-1-hydroxymethyl-2-methylpropyl]-7-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid, GS 9137, GS-9137, GS9137, JTK 303, JTK-303, JTK303
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この商品について
実験式（ヒル表記法）:
C23H23ClFNO5
CAS番号:
分子量:
447.88
UNSPSC Code:
51111800
NACRES:
NA.25
MDL number:
製品名
Elvitegravir, ≥98% (HPLC)
SMILES string
Fc1c(cccc1Cc2cc3c([n](cc([c]3=O)C(=O)O)[C@H](CO)C(C)C)cc2OC)Cl
InChI
1S/C23H23ClFNO5/c1-12(2)19(11-27)26-10-16(23(29)30)22(28)15-8-14(20(31-3)9-18(15)26)7-13-5-4-6-17(24)21(13)25/h4-6,8-10,12,19,27H,7,11H2,1-3H3,(H,29,30)/t19-/m1/s1
InChI key
JUZYLCPPVHEVSV-LJQANCHMSA-N
assay
≥98% (HPLC)
form
powder
optical activity
[α]/D -26 to -34°, c = 0.5 in methanol
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
Quality Level
Biochem/physiol Actions
Elvitegravir (JTK-303; GS-9137) is an orally active human immunodeficiency virus type 1 (HIV-1) integrase inhibitor that prevents HIV-1 replication (EC50 = 0.9 nM using HTLV-I transformed T4-cell line MT-4) by blocking viral DNA to host DNA strand transfer (IC50 = 7.2 nM by cell-free assays).
Orally active human immunodeficiency virus type 1 (HIV-1) integrase strand transfer inhibitor.
signalword
Warning
hcodes
pcodes
Hazard Classifications
Aquatic Acute 1 - Aquatic Chronic 2
保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Motohide Sato et al.
Journal of medicinal chemistry, 49(5), 1506-1508 (2006-03-03)
The viral enzyme integrase is essential for the replication of human immunodeficiency virus type 1 (HIV-1) and represents a remaining target for antiretroviral drugs. Here, we describe the modification of a quinolone antibiotic to produce the novel integrase inhibitor JTK-303
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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