SRP2091
FGF-1 ヒト
recombinant, expressed in insect cells, ≥85% (SDS-PAGE)
別名:
AFGF, ECGF, ECGF-β, ECGFA, ECGFB, FGF-α, FGFA, GLIO703, HBGF1
製品名
FGF-1 ヒト, recombinant, expressed in insect cells, ≥85% (SDS-PAGE)
biological source
human
recombinant
expressed in insect cells
assay
≥85% (SDS-PAGE)
form
frozen liquid
mol wt
~19.2 kDa
packaging
pkg of 5 μg
storage condition
avoid repeated freeze/thaw cycles
concentration
500 μg/mL
color
colorless to clear
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... FGF1(2246)
関連するカテゴリー
Biochem/physiol Actions
酸性線維芽細胞増殖因子(FGF-1)と塩基性線維芽細胞増殖因子(FGF-2)は多くの組織にみられる遍在性のサイトカインです。内皮細胞など中胚葉や神経外胚葉由来の複数の細胞型に影響を及ぼします。FGFタンパク質は、155～268位のアミノ酸残基からなる小型のペプチドです。異なるファミリーメンバー間の配列の同一性の程度は、約120個のアミノ酸からなる「中央ドメイン」で30～60%です。このドメインは、共通の三次構造とヘパリンへの結合能を、FGFに付与します。分泌されるFGFは、細胞表面チロシンキナーゼFGF受容体(FGFR;6、7)に結合し活性化することによって、標的細胞にシグナルを伝達します。いくつかの動物モデルで、胚発達中および成体の生理におけるFGFとFGFRの機能が、機能獲得および機能喪失実験によって検討されました。これらの研究により、FGFが発達イベントの主な調節因子として機能することが示されました。
The protein fibroblast growth factor 1, functions intracellularly to protect cells against stress. The protein functions as an angiogenic factor that participates in tissue repair, carcinogenesis, and maintenance of vasculature stability. Its expression is found to be upregulated in in patients with rheumatic arthritis. It serves as a prognostic biomarker in several cancers and a potential therapeutic target for patients with non-small cell lung cancer.
Physical form
無色透明の凍結した溶液
Preparation Note
手動で霜取りを行う冷凍庫を用いて、凍結-融解サイクルが繰り返されるのを防止してください。作業中は、サンプルを氷中に維持してください。
Application
FGF-1 (fibroblast growth factor 1) has been used as a growth factor to study the effect of FGF1 on early branching events in isolated endoderm obtained from embryonic mouse lung. It has also been used to study the neuroprotection effect of FGF1 on cerebellar granule neurons obtained from rats.
General description
The gene FGF1 (fibroblast growth factor 1) encodes a member of the fibroblast growth factor (FGF) family. It encodes a pro-angiogenic protein that is ubiquitously expressed and is secreted via transmembrane translocation from the cells through a nonclassical secretory pathway in response to stress. It has the ability to permeate membranes composed of acidic phospholipids.
保管分類
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Juan Li et al.
Human pathology, 46(12), 1821-1828 (2015-09-24)
Fibroblast growth factor (FGF) 1 is identified as a candidate cancer biomarker in several kinds of cancer. However, little is known about its expression and function in non-small cell lung cancer (NSCLC). The aim of this study is to identify
Neuroprotection by scatter factor/hepatocyte growth factor and FGF-1 in cerebellar granule neurons is phosphatidylinositol 3-kinase/akt-dependent and MAPK/CREB-independent.
Hossain MA
Journal of Neurochemistry, 81, 365-378 (2002)
Folding of Fibroblast Growth Factor 1 Is Critical for Its Nonclassical Release.
Prudovsky I
Biochemistry, 55, 1159-1167 (2016)
Upregulation of fibroblast growth factor 1 in the synovial membranes of patients with late stage osteoarthritis.
Li R
Genetics and molecular research : GMR, 14, 11191-11199 (2015)
P Cuevas et al.
Neurological research, 17(5), 396-399 (1995-10-01)
The death of spinal axotomised motoneurons provides a useful tool for studying neurotrophic factors which could prevent motoneuron loss in vivo. Median and ulnar nerves of newborn rats were unilaterally sectioned and topically treated with either a vehicle solution or
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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