T0667
トリメトプリム 乳酸塩
≥98%
別名:
2,4-ジアミノ-5-(3,4,5-トリメトキシベンジル)ピリミジン 乳酸塩
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この商品について
実験式（ヒル表記法）:
C14H18N4O3 · C3H6O3
CAS番号:
分子量:
380.40
NACRES:
NA.85
PubChem Substance ID:
UNSPSC Code:
51285203
EC Number:
245-533-1
MDL number:
製品名
トリメトプリム 乳酸塩, ≥98%
InChI key
IIZVTUWSIKTFKO-UHFFFAOYSA-N
InChI
1S/C14H18N4O3.C3H6O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15;1-2(4)3(5)6/h5-7H,4H2,1-3H3,(H4,15,16,17,18);2,4H,1H3,(H,5,6)
SMILES string
CC(O)C(O)=O.COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC
assay
≥98%
form
powder
storage condition
(Keep container tightly closed in a dry and well-ventilated place.)
color
white
solubility
H2O: soluble 20 mg/mL
antibiotic activity spectrum
Gram-negative bacteria
Gram-positive bacteria
mycobacteria
mode of action
DNA synthesis | interferes
enzyme | inhibits
storage temp.
2-8°C
Quality Level
関連するカテゴリー
Application
Trimethoprim is primarily used as an antibacterial agent. It has dihydrofolate reductase inhibitor activity with selectivity for the prokaryote enzyme. It is used clinically to treat urinary tract infections, mild acute prostatitis, recurrent cystitis, asymptomatic bacteriuria during pregnancy and respiratory tract infections. Trimethoprim lactate salt is used as a selection agent.
Biochem/physiol Actions
The combination of trimethoprim and sulfamethoxazole interferes with the cellular metabolism of folic acid in the bacterial cell by blocking the biosynthesis of nucleotides. Trimethoprim binds to prokaryote-specific dihydrofolate reductase (DHFR) and inhibits the reduction of dihydrofolic acid (DHF) to tetrahydrofolic acid (THF). THF is an essential precursor in the thymidine synthesis pathway and interference with this pathway inhibits bacterial DNA synthesis.
General description
Chemical structure: pyrimidine
Other Notes
Keep container tightly closed in a dry and well-ventilated place.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Repr. 2
保管分類
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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