T0826
TBB
≥98% (HPLC), solid
別名:
4,5,6,7-テトラブロモ-2-アザベンゾイミダゾール, 4,5,6,7-テトラブロモベンゾトリアゾール, NSC 231634, TBBt
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この商品について
実験式（ヒル表記法）:
C6HN3Br4
CAS番号:
分子量:
434.71
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
製品名
TBB, ≥98% (HPLC), solid
InChI key
OMZYUVOATZSGJY-UHFFFAOYSA-N
SMILES string
Brc1c(Br)c(Br)c2[nH]nnc2c1Br
InChI
1S/C6HBr4N3/c7-1-2(8)4(10)6-5(3(1)9)11-13-12-6/h(H,11,12,13)
assay
≥98% (HPLC)
form
solid
color
white
solubility
DMSO: 28 mg/mL
storage temp.
2-8°C
Quality Level
Application
TBBは、DNA損傷メディエータータンパク質MDC1のカゼインキナーゼ2依存的リン酸化の研究に使用されています。
Biochem/physiol Actions
TBBは、カゼインキナ-ゼ-2(CK2)に高選択的なATP/GTP競合的阻害剤です(ラット肝臓およびリコンビナントヒトCK2を用いた場合、それぞれIC50 = 900 nMおよび1.6 μM)。
TBBは、カゼインキナーゼ-2のVal66残基に結合し、ATP/GTPの結合を阻害します。TBBは、細胞透過性です；Jurkat細胞において、カスパーゼ依存性のアポトーシスを誘導し、造血系統細胞特異的タンパク質1を分解します。
保管分類
11 - Combustible Solids
wgk
WGK 3
ppe
Eyeshields, Gloves, type N95 (US)
S Sarno et al.
FEBS letters, 496(1), 44-48 (2001-05-10)
The specificity of 4,5,6,7-tetrabromo-2-azabenzimidazole (TBB), an ATP/GTP competitive inhibitor of protein kinase casein kinase-2 (CK2), has been examined against a panel of 33 protein kinases, either Ser/Thr- or Tyr-specific. In the presence of 10 microM TBB (and 100 microM ATP)
Maria Ruzzene et al.
The Biochemical journal, 364(Pt 1), 41-47 (2002-05-04)
Incubation of Jurkat cells with 4,5,6,7-tetrabromobenzotriazole (TBB), a specific inhibitor of protein kinase CK2, induces dose-and time-dependent apoptosis as judged by several criteria. TBB-promoted apoptosis is preceded by inhibition of Ser/Thr phosphorylation of haematopoietic lineage cell-specific protein 1 (HS1) and
J Ross Chapman et al.
EMBO reports, 9(8), 795-801 (2008-06-28)
Mammalian cells respond to DNA double-strand breaks (DSBs) by recruiting DNA repair and cell-cycle checkpoint proteins to such sites. Central to these DNA damage response (DDR) events is the DNA damage mediator protein MDC1. MDC1 interacts with several DDR proteins
Andrew W Bergen et al.
PloS one, 10(7), e0126113-e0126113 (2015-07-02)
The Nicotine Metabolite Ratio (NMR, ratio of trans-3'-hydroxycotinine and cotinine), has previously been associated with CYP2A6 activity, response to smoking cessation treatments, and cigarette consumption. We searched for drug metabolizing enzyme and transporter (DMET) gene variation associated with the NMR
Kate J Treharne et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 24(5-6), 347-360 (2009-11-17)
Deletion of phenylalanine-508 (DeltaF508) from the first nucleotide-binding domain (NBD1) in the wild-type cystic fibrosis (CF) transmembrane-conductance regulator (wtCFTR) causes CF. However, the mechanistic relationship between DeltaF508-CFTR and the diversity of CF disease is unexplained. The surface location of F508
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