T5200

トリパラノール

Name: トリパラノール
Brand: SIGMA

≥97% (HPLC), D24 reductase inhibitor, powder

別名:

1-(4-(2-ジエチルアミノエトキシ)フェニル)-1-p-トリル-2-(4-クロロフェニル)エタノール

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この商品について

実験式（ヒル表記法）:

C₂₇H₃₂NO₂Cl

CAS番号:

78-41-1

分子量:

438.00

NACRES:

NA.77

PubChem Substance ID:

24724632

UNSPSC Code:

12352200

EC Number:

201-115-0

MDL number:

MFCD00865748

Assay:

≥97% (HPLC)

Form:

powder

Quality level:

100

主要文書

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製品名

トリパラノール, ≥97% (HPLC), powder

Quality Level

100

assay

≥97% (HPLC)

form

powder

color

white to off-white

mp

102.9-103.7 °C

solubility

DMSO: 20 mg/mL, H₂O: insoluble, alcohol: soluble, olive oil: slightly soluble

storage temp.

2-8°C

SMILES string

CCN(CC)CCOc1ccc(cc1)C(O)(Cc2ccc(Cl)cc2)c3ccc(C)cc3

InChI

1S/C27H32ClNO2/c1-4-29(5-2)18-19-31-26-16-12-24(13-17-26)27(30,23-10-6-21(3)7-11-23)20-22-8-14-25(28)15-9-22/h6-17,30H,4-5,18-20H2,1-3H3

InChI key

SYHDSBBKRLVLFF-UHFFFAOYSA-N

Gene Information

human ... DHCR24(1718), EBP(10682)

Application

Triparanol has been used to inhibit cholesterol biosynthesis in lipid rafts¹. Triparanol has also been used as a 3β-hydroxysterol-Δ24-reductase inhibitor to study its effect on delayed-rectifier potassium current (I_ks) channels².

Biochem/physiol Actions

デスモステロ-ルδ24(D24)レダクタ-ゼのインヒビタ-です。

Triparanol is known to repress Hedgehog signaling in cancer cells and can also inhibit tumor growth³.

Preparation Note

Triparanol is soluble in DMSO at 20 mg/ml and is also soluble in alcohol. It is slightly soluble in olive oil and is insoluble in water.

pictograms

GHS05,GHS07

signalword

Danger

hcodes

H302,H318

pcodes

P280 - P301 + P312 + P330 - P305 + P351 + P338 + P310

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1

保管分類

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

適用法令

試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。

T5200-25MG: + T5200-BULK: + T5200-IP: + T5200-5MG: + T5200-BULK-CR: + T5200-VAR:

jan

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試験成績書（COA）

Lot/Batch Number

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以前この製品を購入いただいたことがある場合

文書ライブラリで、最近購入した製品の文書を検索できます。

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High affinity of sigma 1-binding sites for sterol isomerization inhibitors: evidence for a pharmacological relationship with the yeast sterol C8-C7 isomerase.

F F Moebius et al.

British journal of pharmacology, 121(1), 1-6 (1997-05-01)

1. The sigma-drug binding site of guinea-pig liver is carried by a protein which shares significant amino acid sequence similarities with the yeast sterol C8-C7 isomerase (ERG2 protein). Pharmacologically-but not structurally-the sigma 1-site is also related to the emopamil binding

Role of cholesterol in embryonic development.

C Roux et al.

The American journal of clinical nutrition, 71(5 Suppl), 1270S-1279S (2000-05-09)

We showed previously that 3 distal inhibitors of cholesterol synthesis are highly teratogenic in rats. AY 9944 and BM 15766 inhibit 7-dehydrocholesterol reductase, which catalyzes the last step of cholesterol synthesis, and triparanol inhibits Delta(24)-dehydrocholesterol reductase, which catalyzes the last

The effects of drugs and chemicals upon the structure of the adrenal gland.

W E Ribelin

Fundamental and applied toxicology : official journal of the Society of Toxicology, 4(1), 105-119 (1984-02-01)

The susceptibility of the endocrine tissues to compound-induced lesions may be ranked in the following decreasing order of frequency: adrenal, testis, thyroid, ovary, pancreas, pituitary, and parathyroid. The first two are by far the most frequently affected. Pathologists unaccustomed to

Fatty acid metabolism in Paramecium. Oleic acid metabolism and inhibition of polyunsaturated fatty acid synthesis by triparanol.

D E Rhoads et al.

Biochimica et biophysica acta, 795(1), 20-29 (1984-08-15)

Paramecium requires oleic acid for growth and can grow in media containing no other fatty acids. In the present study, we have shown that this ciliate utilized oleate mainly as a carbon and energy source, even though this fatty acid

Regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase in human hepatoma cell line Hep G2. Effects of inhibitors of cholesterol synthesis on enzyme activity.

A Boogaard et al.

The Biochemical journal, 241(2), 345-351 (1987-01-15)

Incubating Hep G2 cells for 18 h with triparanol, buthiobate and low concentrations (less than 0.5 microM) of U18666A, inhibitors of desmosterol delta 24-reductase, of lanosterol 14 alpha-demethylase and of squalene-2,3-epoxide cyclase (EC 5.4.99.7) respectively, resulted in a decrease of

トリパラノール

≥97% (HPLC), D24 reductase inhibitor, powder

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この商品について

主要文書

特性

製品名

Quality Level

assay

form

color

mp

solubility

storage temp.

SMILES string

InChI

InChI key

Gene Information

関連するカテゴリー

詳細

Application

Biochem/physiol Actions

Preparation Note

安全性情報

pictograms

signalword

hcodes

pcodes

Hazard Classifications

保管分類

wgk

flash_point_f

flash_point_c

ppe

適用法令

T5200-25MG: + T5200-BULK: + T5200-IP: + T5200-5MG: + T5200-BULK-CR: + T5200-VAR:

資料

試験成績書（COA）

以前この製品を購入いただいたことがある場合

参考文献

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