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Merck

T5293

モノクロナール抗β-チューブリン マウス宿主抗体

clone 2-28-33, ascites fluid

別名:

Anti-β-Tubulin Antibody

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この商品について

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
MFCD00145892

主要文書

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製品名

モノクロナール抗β-チューブリン マウス宿主抗体, clone 2-28-33, ascites fluid

biological source

mouse

conjugate

unconjugated

antibody form

ascites fluid

antibody product type

primary antibodies

clone

2-28-33, monoclonal

contains

15 mM sodium azide

species reactivity

Ciona intestinalis, rat, chicken, Caenorhabditis elegans, Strongylocentrotus purpuratus, bovine, human

enhanced validation

independent ( Antibodies)
Learn more about Antibody Enhanced Validation

technique(s)

indirect immunofluorescence: 1:1,000 using cultured chicken fibroblasts or cultured human foreskin fibroblasts
western blot: 1:100

isotype

IgG1

UniProt accession no.

Q9H4B7

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

200

Gene Information

human ... TUBB1(81027), TUBB2A(7280), TUBB2C(10383)
rat ... Tubb2(29212), Tubb2c(296554)

関連するカテゴリー

Biochem/physiol Actions

抗体は、自由生活性土壌線虫C. elegans.のβ-チュ-ブリンの代表的な2種類のアイソフォ-ムと1種類の少数アイソフォ-ムを認識します。また、Strongylocentrotus purpuratus精子軸糸由来のサルコシル耐性リボンや幼生ホヤ(Ciona intestinalis)の神経軸索をはじめ、ニワトリや哺乳動物、培養ヒト繊維芽細胞、ウシおよびラット脳組織のチュ-ブリンとも結合します。線虫C.elegansサンプルの場合、抗体は等電点電気泳動ゲルで分離されたチュ-ブリンには結合しますが、SDSやβ-メルカプトエタノ-ル存在下で熱変性したチュ-ブリンは認識しません。哺乳類サンプルのイムノブロッティングでは、熱変性や還元処理しても反応します。
Mutation in the gene leads to various neuronal migration disorders such as lissencephaly, pachygyria and polymicrogyria malformations. B2702 peptide binds to β-tubulin and inhibits NK cell cytotoxicity and it influences microtubule polymerization, which damages cytoskeleton organization and chaperone-like activity of tubulin. β-1 tubulin also known as class VI or TUBB1, plays a vital role in platelet production, and is considered to be a potential biomarker candidate for immune thrombocytopenia (ITP).

Immunogen

Strongylocentrotus purpuratus(ウニ)精子軸糸由来のサルコシル耐性リボン。

Application

Monoclonal Anti-β-Tubulin antibody produced in mouse has been used in western blotting and fluorescence immunocytochemical staining.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

β-Tubulin belongs to the subfamily of tubulin, which is the major building block of microtubules. β-tubulin has a molecular weight of 55kDa. β-Tubulin structure is characterized with core of two β-sheets enclosed by α-helices. It also contains an N-terminal domain with the guanine nucleotide-binding region, an intermediate domain with taxol-binding site, and a C-terminal domain that contains the binding surface for molecular motor proteins.Human β-tubulin consists of seven isoforms (βI (class I), βII (class II), βIII (class III), βIVa (class IVa), βIVb (class IVb), βV (class V), and βVI (class VI)).

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保管分類

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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試験成績書（COA）

Lot/Batch Number
059M4862V
059M4861V
038M4856V
047M4798V
066M4751V

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Peter D Caie et al.
Molecular cancer therapeutics, 9(6), 1913-1926 (2010-06-10)
The application of high-content imaging in conjunction with multivariate clustering techniques has recently shown value in the confirmation of cellular activity and further characterization of drug mode of action following pharmacologic perturbation. However, such practical examples of phenotypic profiling of
Michael E Hall et al.
American journal of physiology. Heart and circulatory physiology, 301(1), H253-H260 (2011-05-04)
The Cre-loxP system is a useful tool to study the physiological effects of gene knockout in the heart. One limitation with using this system in the heart is the toxic effect of chronic expression of the Cre recombinase. To circumvent
Birth of Piglets After Transfer of Embryos Cryopreserved by Cytoskeletal Stabilization and Vitrification
Dobrinsky JR
Biology of Reproduction, 62, 564-570 (2000)
Tilman Jobst-Schwan et al.
American journal of physiology. Renal physiology, 305(5), F734-F744 (2013-07-05)
The inhibitor of apoptosis protein survivin is a bifunctional molecule that regulates cellular division and survival. We have previously shown that survivin protein can be found at high concentrations in the adult kidney, particularly in the proximal tubules. Here, survivin
Hanna S Radomska et al.
The Journal of clinical investigation, 122(8), 2955-2966 (2012-07-17)
Mutations that activate the fms-like tyrosine kinase 3 (FLT3) receptor are among the most prevalent mutations in acute myeloid leukemias. The oncogenic role of FLT3 mutants has been attributed to the abnormal activation of several downstream signaling pathways, such as
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資料

Antibodies to Tubulins, including Centrosome-Associated ε-Tubulin

Microtubules of the eukaryotic cytoskeleton are composed of a heterodimer of α- and β-tubulin. In addition to α-and β-tubulin, several other tubulins have been identified, bringing the number of distinct tubulin classes to seven.

εチューブリンを含むチューブリンに対する抗体

αチューブリンとβチューブリンのヘテロダイマーで構成される真核細胞の細胞骨格の微小管には、多様な機能を発揮する複数の明確なチューブリンクラスがあります。

ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.

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