T6069
チオ-TEPA
別名:
N,N′,N″-トリエチレンチオホスホルアミド, Thio-Tep, チオテフ, チオフォシル, チオフォジル, チオホジル, チオホスファミド, トリス(アジリジニル)ホスフィンスルフィド
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この商品について
実験式（ヒル表記法）:
C6H12N3PS
CAS番号:
分子量:
189.22
NACRES:
NA.85
PubChem Substance ID:
UNSPSC Code:
51102829
EC Number:
200-135-7
MDL number:
InChI key
FOCVUCIESVLUNU-UHFFFAOYSA-N
InChI
1S/C6H12N3PS/c11-10(7-1-2-7,8-3-4-8)9-5-6-9/h1-6H2
SMILES string
S=P(N1CC1)(N2CC2)N3CC3
form
solid
storage condition
(Keep container tightly closed in a dry and well-ventilated place.)
color
white
antibiotic activity spectrum
neoplastics
mode of action
DNA synthesis | interferes
storage temp.
2-8°C
Quality Level
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関連するカテゴリー
Analysis Note
可溶性-水、クロロホルムおよびエタノール（96%）に溶けやすい
Application
多官能性アルキル化剤。
Biochem/physiol Actions
不安定な窒素－炭素基はDNAとアルキル化し、それが不可逆的なDNA損傷を引き起こします。DNA二重らせんのグアニン核酸塩基に架橋することでDNAを直接攻撃し、腫瘍増殖を停止させます。DNA鎖はほどけて分離することができないため、細胞分裂が停止します。
General description
化学構造：アジリジン
Other Notes
容器は、乾燥した換気の良い場所にしっかり密閉して保管してください。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 2 Oral - Carc. 1B
保管分類
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
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ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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