U0750
ウラシル
≥99.0%, synthetic (organic), powder
別名:
2,4(1H,3H)-ピリミジンジオン, 2,4-ジヒドロキシピリミジン, 2,4-ピリミジンジオール
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この商品について
実験式（ヒル表記法）:
C4H4N2O2
CAS番号:
分子量:
112.09
NACRES:
NA.51
PubChem Substance ID:
UNSPSC Code:
41106305
EC Number:
200-621-9
MDL number:
Beilstein/REAXYS Number:
507828
製品名
ウラシル, ≥99.0%
InChI key
ISAKRJDGNUQOIC-UHFFFAOYSA-N
InChI
1S/C4H4N2O2/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8)
SMILES string
O=C1NC=CC(=O)N1
biological source
synthetic (organic)
assay
≥99.0%
form
powder
mp
>300 °C (lit.)
solubility
1 M NaOH: 50 mg/mL, clear to hazy, colorless to faint yellow or tan
Quality Level
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関連するカテゴリー
Application
ウラシルは、次の用途で使用されています：
- 高速液体クロマトグラフィーによるDNAメチル化の測定のためのヌクレオチドスタンダード
- Saccharomyces cerevisiae（酵母）およびその菌株の培養のための合成限定培地の成分として
- Bacillus （バシラス）属の培養のためのアミノ酸サプリメントの成分として
Biochem/physiol Actions
ウラシルおよびその誘導体は、がん、ウイルス感染、常染色体劣性遺伝疾患、甲状腺、糖尿病の薬の合成のための医薬品化学において欠かせない役割を担っています。
General description
ウラシルは、ピリミジン核酸塩基ファミリーに属しています。天然に存在し、RNAの重要な活性部分です。
保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Sandra M Carvalho et al.
PloS one, 8(3), e58492-e58492 (2013-03-19)
Links between carbohydrate metabolism and virulence in Streptococcus pneumoniae have been recurrently established. To investigate these links further we developed a chemically defined medium (CDM) and standardized growth conditions that allowed for high growth yields of the related pneumococcal strains
William B White et al.
The New England journal of medicine, 369(14), 1327-1335 (2013-09-03)
To assess potentially elevated cardiovascular risk related to new antihyperglycemic drugs in patients with type 2 diabetes, regulatory agencies require a comprehensive evaluation of the cardiovascular safety profile of new antidiabetic therapies. We assessed cardiovascular outcomes with alogliptin, a new
Daisuke Katagiri et al.
Journal of the American Society of Nephrology : JASN, 24(12), 2034-2043 (2013-10-05)
Accumulating evidence of the beyond-glucose lowering effects of a gut-released hormone, glucagon-like peptide-1 (GLP-1), has been reported in the context of remote organ connections of the cardiovascular system. Specifically, GLP-1 appears to prevent apoptosis, and inhibition of dipeptidyl peptidase-4 (DPP-4)
Jaunius Urbonavicius et al.
Methods in enzymology, 425, 103-119 (2007-08-04)
Formation of 5-methyluridine (ribothymidine) at position 54 of the T-psi loop of tRNA is catalyzed by site-specific tRNA methyltransferases (tRNA[uracil-54,C5]-MTases). In eukaryotes and many bacteria, the methyl donor for this reaction is generally S-adenosyl-L-methionine (S-AdoMet). However, in other bacteria, like
Mirta M L Sousa et al.
Molecular aspects of medicine, 28(3-4), 276-306 (2007-06-26)
Uracil is usually an inappropriate base in DNA, but it is also a normal intermediate during somatic hypermutation (SHM) and class switch recombination (CSR) in adaptive immunity. In addition, uracil is introduced into retroviral DNA by the host as part
資料
A shortened review of fundamentals of Porous Graphitic Carbon (PGC) materials. What they are and how do they work as a stationary phase material in HPLC?.
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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