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KitAlysis™ High-Throughput Buchwald-Hartwig Amination Reaction Screening Kit-Pack of 4

Synonym(s):

Amination Screening Kit, Buchwald-Hartwig Amination

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About This Item

NACRES:
NA.22
UNSPSC Code:
12161503
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product line

KitAlysis™

reaction suitability

reaction type: Buchwald-Hartwig Cross Coupling Reaction, reaction type: Cross Couplings, reagent type: catalyst
core: palladium

storage temp.

room temp

General description

The KitAlysis™ High Throughput Buchwald–Hartwig Amination Reaction Screening Kit enables chemists to quickly and efficiently screen Buchwald–Hartwig C–N cross-coupling reaction conditions. Quick identification of optimal conditions allows faster scale-up of the synthetic reaction. All required chemicals come pre-weighed for ease of use. A step-by-step user guide and experimental excel sheets are available for download to facilitate the process.

Application

There are four possible screens that can be run based upon the user’s substrates. Step-by-step user guides and a downloadable experimental excel sheets for each screen is provided in the below hyperlinks.

Two Solvents, Weak Base (Cs2CO3)
Download the experimental excel file here
Two Solvents, Strong Base (NaOt-Bu)
Download the experimental excel file here
One Solvent (Dioxane), Two Bases
Download the experimental excel file here
One Solvent (DMAc), Two Bases
Download the experimental excel file here

Each kit contains 4 screening sets that contain the following:
Each customizable screening kit contains



  • 12 X 2 pre-weighed catalysts (1 μmol) in individual microvials with magnetic stir bars
  • 2 bases (NaOt-Bu and Cs2CO3)
  • 2 degassed anhydrous solvents (dioxane and DMAc) in ampules
  • 2 substrate reaction vials with stir bars
  • 1 internal standard
  • 4 reaction block replacement films
Monitor reaction progress via TLC-MS by following this protocol

Best when used with KitAlysis Benchtop Inertion Box and 24-well Reaction Block (sold separately).

Features and Benefits

  • Designed and tested by synthetic chemists
  • Easily run 24-microscale reaction in parallel
  • 10 μmol reactions with 1 μmol catalyst, 3 equiv. base, 0.1 M concentration
  • Customizable Excel Template for quick calculations and easy incorporation into electronic laboratory notebooks

Legal Information

KitAlysis is a trademark of Sigma-Aldrich Co. LLC

Kit Components Only

Product No.
Description
  • SnapIT Ampule Opener, Regular, for 1-2ml, 5-10ml, 10-15ml ampoules 1 EA

Kit Components Also Available Separately

Product No.
Description
SDS & Pricing
  • 900634
    N,N-Dimethylacetamide, anhydrous, ZerO2®, 99.8% 8 mL
    SDS
  • 900640
    1,4-Dioxane, anhydrous, ZerO2®, 99.8% 8 mL
    SDS
  • 702706
    Sodium tert-butoxide solution, 2 M in THF, ZerO2® 4 mL
    SDS
  • 747130
    Josiphos SL-J009-1 Pd G3 5 µmol
    SDS
  • 753009
    SPhos Pd G2 5 µmol
    SDS
  • 753246
    RuPhos Pd G2 5 µmol
    SDS
  • 756482
    P(t-Bu)3 Pd G2 5 µmol
    SDS
See All (15)

signalword

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1B - Eye Dam. 1 - Repr. 1B - Self-heat. 1 - Skin Corr. 1B - STOT RE 2 Oral - STOT SE 3

target_organs

Central nervous system, Kidney,Adrenal gland,Testes, Respiratory system

Storage Class

4.2 - Pyrophoric and self-heating hazardous materials

flash_point_f

-4.0 °F - closed cup

flash_point_c

-20 °C - closed cup

wgk

WGK 3

supp_hazards

EUH014,EUH019

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

Please refer to KIT Component information

pdsc

Please refer to KIT Component information

prtr

Please refer to KIT Component information

fsl

Please refer to KIT Component information

ishl_indicated

Please refer to KIT Component information

ishl_notified

Please refer to KIT Component information

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