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Merck

343922

Sigma-Aldrich

5-Fluorouracil

≥98% (HPLC), solid, thymidylate synthase inhibitor, Calbiochem®

Synonym(s):

5-Fluorouracil, 5-FU

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About This Item

Empirical Formula (Hill Notation):
C4H3FN2O2
CAS Number:
51-21-8
Molecular Weight:
130.08
MDL number:
MFCD00006018
UNSPSC Code:
12171500
NACRES:
NA.77

Key Documents

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Product Name

5-Fluorouracil, Potent antitumor agent.

description

Merck USA index - 14, 4181

Quality Level

100

Assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

white

solubility

hot water: 1 mg/mL
methanol: 1 mg/mL
DMF: 5 mg/mL
DMSO: 5 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

Fc1[c]([nH][c]([nH]c1)=O)=O

InChI

1S/C4H3FN2O2/c5-2-1-6-4(9)7-3(2)8/h1H,(H2,6,7,8,9)

InChI key

GHASVSINZRGABV-UHFFFAOYSA-N

General description

Potent antitumor agent that inhibits aminoisobutyrate-pyruvate aminotransferase. Induces apoptosis of human colon cancer cell lines.
Potent antitumor agent. Inhibits aminoisobutyrate-pyruvate aminotransferase. Induces apoptosis in human colon cancer cell lines.

Biochem/physiol Actions

Cell permeable: no
Primary Target
Aminoisobutyrate-pyruvate aminotransferase
Product does not compete with ATP.
Reversible: no

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Pressacco, J., et al. 1996. Br. J. Cancer72, 939.
Shchepotin, I.B., et al. 1994. Anticancer Res.14, 1027.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful (C)

Pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

Signal Word

Danger

Hazard Statements

H301,H351

Hazard Classifications

Acute Tox. 3 Oral - Carc. 2

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Certificates of Analysis (COA)

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Articles

중요하게 고려해야 할 억제제 특성

세포 투과성, 프로존 효과, 리핀스키의 5 규칙 등의 효소 억제제로 작업 시 중요하게 고려해야 할 특성을 알아보세요.

Critical Inhibitor Characteristics to Consider

Discover critical characteristics to consider when working with enzyme inhibitors, such as cell permeability, the prozone effect, and Lipinski’s rule of 5.

Global Trade Item Number

SKUGTIN
343922-1GMCN04055977195132