PHR1146
Ibuprofen Related Compound C
Pharmaceutical Secondary Standard; Certified Reference Material
Synonym(s):
4′-Isobutylacetophenone, 1-(4-Isobutylphenyl)ethanone, 1-Acetyl-4-isobutylbenzene
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About This Item
Empirical Formula (Hill Notation):
C12H16O
CAS Number:
Molecular Weight:
176.25
UNSPSC Code:
41116107
EC Number:
254-159-8
NACRES:
NA.24
grade
certified reference material, pharmaceutical secondary standard
agency
USP 1335541
API family
ibuprofen
CofA
current certificate can be downloaded
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
SMILES string
O=C(C)c1ccc(cc1)CC(C)C
InChI
1S/C12H16O/c1-9(2)8-11-4-6-12(7-5-11)10(3)13/h4-7,9H,8H2,1-3H3
InChI key
KEAGRYYGYWZVPC-UHFFFAOYSA-N
General description
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
It is an impurity of the nonsteroidal anti-inflammatory drug (NSAID)― ibuprofen and presents itself as a degradation product of the parent drug. It is used for the treatment of mild and moderate pain such as during rheumatoid arthritis, osteoarthritis, and dysmenorrhea.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
It is an impurity of the nonsteroidal anti-inflammatory drug (NSAID)― ibuprofen and presents itself as a degradation product of the parent drug. It is used for the treatment of mild and moderate pain such as during rheumatoid arthritis, osteoarthritis, and dysmenorrhea.
Application
This pharmaceutical secondary standard can also be used as follows:
- Simultaneous determination of ibuprofen and its 17 related impurities by an ICH validated reversed-phase high-performance liquid chromatography (RP-HPLC) method in tablets
- Analysis of combined dosage tablet of ibuprofen and famotidine for their quantitative estimation in the presence of their impurities using thin layer chromatography (TLC) and HPLC
Analysis Note
These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.
Other Notes
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
To see an example of a Certificate of Analysis for this material enter LRAB2151 in the slot below. This is an example certificate only and may not be the lot that you receive.
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signalword
Warning
hcodes
Hazard Classifications
Aquatic Chronic 2 - Skin Irrit. 2 - Skin Sens. 1B
Storage Class
10 - Combustible liquids
flash_point_f
286.7 °F - closed cup
flash_point_c
141.5 °C - closed cup
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