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C239

CNQX disodium salt hydrate

Name: CNQX disodium salt hydrate
Brand: SIGMA

≥98% (HPLC), solid, AMPA/kainate receptor antagonist.

Synonym(s):

6-Cyano-7-nitroquinoxaline-2,3-dione disodium salt hydrate

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About This Item

Empirical Formula (Hill Notation):

C₉H₂N₄Na₂O₄ · xH₂O

CAS Number:

115066-14-3

Molecular Weight:

276.12 (anhydrous basis)

UNSPSC Code:

12352200

PubChem Substance ID:

24277972

NACRES:

NA.77

MDL number:

MFCD09953908

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

100

Storage condition:

protect from light

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Properties

Product Name

CNQX disodium salt hydrate, ≥98% (HPLC), solid

Quality Level

100

assay

≥98% (HPLC)

form

solid

storage condition

protect from light

color

orange to red

solubility

H₂O: >2 mg/mL (warmed)

SMILES string

O.[Na+].[Na+].[O-]c1nc2cc(C#N)c(cc2nc1[O-])[N+]([O-])=O

InChI

1S/C9H4N4O4.2Na.H2O/c10-3-4-1-5-6(2-7(4)13(16)17)12-9(15)8(14)11-5;;;/h1-2H,(H,11,14)(H,12,15);;;1H2/q;2*+1;/p-2

InChI key

LCDWHGXMFAZHEO-UHFFFAOYSA-L

Gene Information

human ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140), GRIA1(2890), GRIA2(2891), GRIA3(2892), GRIA4(2893)

Description

Application

CNQX disodium salt hydrate has been used as:

as a competitive non-NMDA receptor antagonist and competitive AMPA/kainate receptor antagonist in neuronal cultures(110)
as a glutamatergic blockers for measuring inhibitory postsynaptic currents in projection neurons(111)
as a AMPA glutamate receptor antagonist prefrontal cortex neurons(112)

Biochem/physiol Actions

CNQX(6-cyano-7-nitroquinoxaline-2,3-dioneis) is a potent, competitive AMPA/kainate receptor antagonist. It is a quinoxaline derivative and also an antagonist for non-N-methyl-d-aspartate (non-NMDA) glutamate receptor. CNQX mediates depolarization thalamic reticular nucleus via α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors (AMPARs). It displays micromolar affinity towards AMPA/kainate receptor.

Potent, competitive AMPA/kainate receptor antagonist.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Articles

DISCOVER Bioactive Small Molecules for Neuroscience

신경과학을 위한 생체 활성 저분자

CNQX Blocks Kainate-induced Corneal Irritation

Ibitokun, Bernadette O and Miller, Kenneth E

investigate opthalmology and visual science, 53(14), 1855-1855 (2012)

Ultrafast Two-Photon Imaging of a High-Gain Voltage Indicator in Awake Behaving Mice.

Vincent Villette et al.

Cell, 179(7), 1590-1608 (2019-12-14)

Optical interrogation of voltage in deep brain locations with cellular resolution would be immensely useful for understanding how neuronal circuits process information. Here, we report ASAP3, a genetically encoded voltage indicator with 51% fluorescence modulation by physiological voltages, submillisecond activation

Medicinal chemistry of competitive kainate receptor antagonists

Larsen, Ann M and Bunch, Lennart

ACS Chemical Neuroscience, 2(2), 60-74 (2010)

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