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G7127

Guanosine 5′-diphosphate sodium salt

Name: Guanosine 5&#8242;-diphosphate sodium salt
Brand: SIGMA

≥96% (HPLC), synthetic (organic), powder

Synonym(s):

GDP

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About This Item

Empirical Formula (Hill Notation):

C₁₀H₁₅N₅O₁₁P₂

CAS Number:

43139-22-6

Molecular Weight:

443.20

UNSPSC Code:

41106305

PubChem Substance ID:

24895291

NACRES:

NA.51

MDL number:

MFCD00070121

Assay:

≥96% (HPLC)

Biological source:

synthetic (organic)

Form:

powder

Solubility:

water: 50 mg/mL, clear, colorless

Storage temp.:

−20°C

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Properties

Product Name

Guanosine 5′-diphosphate sodium salt, Type I, ≥96% (HPLC)

biological source

synthetic (organic)

Quality Level

300

type

Type I

assay

≥96% (HPLC)

form

powder

solubility

water: 50 mg/mL, clear, colorless

shipped in

dry ice

storage temp.

−20°C

SMILES string

[Na].NC1=NC(=O)c2ncn(C3OC(COP(O)(=O)OP(O)(O)=O)C(O)C3O)c2N1

InChI

1S/C10H15N5O11P2.Na.H/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21;;/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18);;

InChI key

PVMPTWQLNDHIEV-UHFFFAOYSA-N

Description

Application

Guanosine 5′-diphosphate sodium salt has been used:

in GTP-γ-35S functional assays
in Y1 agonist-stimulated [35S]- guanosine-5′-O-(3-thio)triphosphate (GTPγS) functional binding
in the expression and purification of recombinant proteins

Biochem/physiol Actions

Guanosine 5′-diphosphate (GDP) is the diphosphate nucleoside of the purine guanine. GDP and GTP are involved in and may be used to study cell signaling via G-coupled protein receptors (GCPR) and guanine nucleotide exchange factors (GEF) and a variety of GTPases.

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

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Protocols

HPLC Analysis of GMP, GDP and GTP on SeQuant ZIC-HILIC

LC/MS Analysis of Nucleotides on SeQuant ZIC-cHILIC

HILIC separation is an alternative that permits sensitive MS detection and without the use of ion-pair reagents.

LC/MS Analysis of Nucleotides SeQuant^® ZIC^®-cHILIC – Effect of pH

ZIC^®-cHILIC is a densely bonded zwitterionic stationary phase with phosphorylcholine functional groups covalently attached to silica.