K1639
K-252a
from Nonomuraea longicatena, ≥98% (HPLC)
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About This Item
Empirical Formula (Hill Notation):
C27H21N3O5
CAS Number:
Molecular Weight:
467.47
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
biological source
Nonomuraea longicatena
Quality Level
assay
≥98% (HPLC)
form
solid
solubility
DMF: 1 mg/mL, DMSO: 1 mg/mL
antibiotic activity spectrum
viruses
mode of action
enzyme | inhibits
shipped in
dry ice
storage temp.
−20°C
SMILES string
[H][C@]12C[C@](O)(C(=O)OC)[C@](C)(O1)n3c4ccccc4c5c6CNC(=O)c6c7c8ccccc8n2c7c35
InChI
1S/C27H21N3O5/c1-26-27(33,25(32)34-2)11-18(35-26)29-16-9-5-3-7-13(16)20-21-15(12-28-24(21)31)19-14-8-4-6-10-17(14)30(26)23(19)22(20)29/h3-10,18,33H,11-12H2,1-2H3,(H,28,31)/t18-,26+,27+/m1/s1
InChI key
KOZFSFOOLUUIGY-SOLYNIJKSA-N
Gene Information
human ... NTRK1(4914)
rat ... Prkca(24680)
Application
K-252a has been used:
- as a tropomyosin receptor kinase (Trk) inhibitor to study the role of TrkA signaling in rats
- as a Trk inhibitor for inducing in vitro injury in retinal Müller glial cells to study the effects of cord blood serum (CBS)
- as a general protein kinase inhibitor to study its effect on in vitro human somatic testicular cell reassembly
Biochem/physiol Actions
K-252a is a selective inhibitor of tyrosine protein kinase. It targets a wide range of protein kinases with IC50 values between 3 and 25nM and the neurotrophin receptor-tropomyosin receptor kinase.
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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