SML0034
1-EBIO
≥98% (HPLC)
Synonym(s):
1-Ethyl-1,3-dihydro-2H-benzimidazol-2-one; 1-Ethylbenzimidazolinone
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About This Item
Empirical Formula (Hill Notation):
C9H10N2O
CAS Number:
Molecular Weight:
162.19
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
233-148-1
MDL number:
Quality Level
assay
≥98% (HPLC)
form
powder
solubility
DMSO: ≥20 mg/mL
storage temp.
room temp
SMILES string
CCN1C(=O)Nc2ccccc12
InChI
1S/C9H10N2O/c1-2-11-8-6-4-3-5-7(8)10-9(11)12/h3-6H,2H2,1H3,(H,10,12)
InChI key
CXUCKELNYMZTRT-UHFFFAOYSA-N
Application
1-EBIO was used to study the electrical activity modulated by Ca+2-activated K+ channels in rat central neurons. The effect of 1-EBIO on human intermediate conductance channels was studied.
Biochem/physiol Actions
1-EBIO is an activator of epithelial Ca2+-activated K+ channel also known as the intermediate-conductance Ca(2+)-activated K(+) channel (IK-1) or KCa3.1.
1-EBIO is an activator of epithelial Ca2+-activated K+ channel
1-EBIO potentiates the secretion of CFTR-mediated Cl− ion secretion by activating the basolateral KCNN4 K+ channels in native human colonic tissues. It stimulates the apical Cl− channels and Ca+2-dependent basolateral K+ channels to stimulate fluid transport in lacrimal glands.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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