SML0409
STF-083010
≥98% (HPLC)
Synonym(s):
N-[(2-Hydroxy-1-naphthalenyl)methylene]-2-thiophenesulfonamide
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About This Item
Empirical Formula (Hill Notation):
C15H11NO3S2
CAS Number:
Molecular Weight:
317.38
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Quality Level
assay
≥98% (HPLC)
form
powder
color
light yellow to yellow-green
solubility
DMSO: 5 mg/mL (clear solution)
storage temp.
−20°C
SMILES string
OC1=C(/C=N/S(C2=CC=CS2)(=O)=O)C3=C(C=CC=C3)C=C1
InChI
1S/C15H11NO3S2/c17-14-8-7-11-4-1-2-5-12(11)13(14)10-16-21(18,19)15-6-3-9-20-15/h1-10,17H/b16-10+
InChI key
TVIVJHZHPKNDAQ-MHWRWJLKSA-N
Application
STF-083010 has been used:
- in a study to investigate the potential anti-lipotoxic effect of nicotinamide and to elucidate underlying mechanism(s)
- as IRE1a inhibitor to study its effect on NOS 2 expression and investigate the underlying mechanisms in proinflammatory gene expression in astrocytes
- to block endogenous XBP1 cleavage for one hour prior to palmitate exposure in order to examine whether inositol?requiring enzyme 1α (IRE1α ) activation is implicated in palmitate cytotoxicity
Biochem/physiol Actions
STF-083010 is a potent inhibitor of IRE-1 mRNA splicing activity.
STF-083010 is a potent inhibitor of the ER transmembrane protein IRE1, which mediates the unfolded protein response. STF-083010 inhibits IRE1 endonuclease and mRNA splicing activity in response to endopasmic reticulum (ER) stress, but has no affect on the kinase activity of IRE1.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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