138630
1-Chloro-2,4-dinitrobenzene
97%
동의어(들):
2,4-Dinitrochlorobenzene, CDNB, DNCB
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제품정보 (DICE 배송 시 비용 별도)
Linear Formula:
ClC6H3(NO2)2
CAS 번호:
Molecular Weight:
202.55
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
202-551-4
Beilstein/REAXYS Number:
613161
MDL number:
Assay:
97%
Form:
solid
Quality Segment
assay
97%
form
solid
expl. lim.
22 %
bp
315 °C (lit.)
mp
48-50 °C (lit.)
solubility
alcohol: soluble (hot), alcohol: very slightly soluble (cold), benzene: soluble, carbon disulfide: soluble, diethyl ether: soluble, water: insoluble
functional group
chloro, nitro
SMILES string
[O-][N+](=O)c1ccc(Cl)c(c1)[N+]([O-])=O
InChI
1S/C6H3ClN2O4/c7-5-2-1-4(8(10)11)3-6(5)9(12)13/h1-3H
InChI key
VYZAHLCBVHPDDF-UHFFFAOYSA-N
Application
1-Chloro-2,4-dinitrobenzene was used in determination of relative amounts of individual glutathione S-transferases subunits in human tissues by reverse-phase HPLC. It was used as contact sensitizer to study the antibacterial peptides hBD-2, -3 and -4 and LL-37 induced IL-18 protein release in human keratinocytes.
Biochem/physiol Actions
2,4-dinitrochlorobenzene induces atopic dermatitis in BALB/c mice model.
Preparation Note
The product is dissolved in ethanol when used as glutathione S-transferase substrate and then added to a buffer to form a final concentration of 1mM in phosphate buffer (8 mL of 0.2 M KH2PO4 and 28 mL of 0.1 M Na2HPO4 per 100 mL of solution, adjusted to pH 6.5) and 4% (v/v) ethanol.
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Danger
Hazard Classifications
Acute Tox. 2 Dermal - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Irrit. 2 - Skin Sens. 1
저장 등급
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 2
flash_point_f
381.2 °F - closed cup
flash_point_c
194 °C - closed cup
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Mingli Sun et al.
Molecular medicine reports, 9(2), 689-694 (2013-12-18)
Bacillus Calmette-Guerin extract (BCGE) has been proven to be clinically effective for anaphylactic disease, infectious diseases and cancer. In this study, we investigated the effect of the intramuscular application of BCGE on 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD). We established an
J D Rowe et al.
The Biochemical journal, 325 ( Pt 2), 481-486 (1997-07-15)
Uncertainties about the composition and identities of glutathione S-transferases (GSTs) in human tissue have impeded studies on their biological functions. A rigorous protocol has therefore been developed to characterize the human proteins. Cytosolic GST subunits were resolved by reverse-phase HPLC
Antony Anet et al.
Journal of hazardous materials, 370, 42-53 (2018-09-15)
This study investigates Bisphenol A (BPA) induced oxidative stress that mediates the genotoxicity in in vivo model Drosophila melanogaster. The calculated LC50 for BPA was 12.35 μg/mL. The strains of D. melanogaster were reared in 0.1, 1.0, 2.5 and 5.0 μg/mL BPA