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제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C45H94N3O19P3
CAS 번호:
Molecular Weight:
1074.16
MDL number:
UNSPSC Code:
51191904
NACRES:
NA.25
description
1,2-dioleoyl-sn-glycero-3-phospho-(1′-myo-inositol-4′,5′-bisphosphate) (ammonium salt)
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 100 μg (with stopper and crimp cap (850155P-100ug)), pkg of 1 × 500 μg (with stopper and crimp cap (850155P-500ug))
manufacturer/tradename
Avanti Research™ - A Croda Brand
lipid type
phospholipids
cardiolipins
shipped in
dry ice
storage temp.
−20°C
SMILES string
[H][C@@](COP([O-])(O[C@H]1[C@H](O)[C@@H](OP(O)([O-])=O)[C@H](OP([O-])(O)=O)[C@@H](O)[C@H]1O)=O)(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O.[NH4+].[NH4+].[NH4+]
General description
Although PI(4,5)P2 is a minor component of cell membranes, it plays a critical role as a substrate for a number of important signaling proteins. PI(4,5)P2 is an intermediate in the IP3/DAG pathway where it is hydrolyzed by phospholipase C to liberate the second messengers, inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). PI(4,5)P2 is also a substrate for PI 3-kinase where it is phosphorylated to PI(3,4,5)P3, an activator of downstream signaling components such as the protein kinase AKT.
Phosphatidylinositol is a structural phospholipid. Phosphatidylinositol phosphate (PIP) is located in the plasma membrane.
Application
18:1 PI(4,5)P2 is suitable to use as a supplement in native macrophage membranes to generate phospholipid enriched membrane liposome.s It has also been used:
- in the preparation of anionic phospholipid liposomes
- as a component in supported membrane tube (SMrT) templates
- in liposome preparation
Biochem/physiol Actions
Phosphatidylinositol bisphosphate (PIP2) can effectively stimulate the ATPase.
Packaging
2 mL Amber Serum Vial with Stopper and Crimp Cap (850155P-100ug)
2 mL Amber Serum Vial with Stopper and Crimp Cap (850155P-500ug)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
저장 등급
11 - Combustible Solids
wgk
WGK 3