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제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C25H58N3O19P3
CAS 번호:
Molecular Weight:
797.66
UNSPSC Code:
51191904
NACRES:
NA.25
description
1,2-dioctanoyl-sn-glycero-3-phospho-(1′-myo-inositol-4′,5′-bisphosphate) (ammonium salt)
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 100 μg (with stopper and crimp cap (850185P-100ug)), pkg of 1 × 500 μg (with stopper and crimp cap (850185P-500ug))
manufacturer/tradename
Avanti Research™ - A Croda Brand
lipid type
cardiolipins
phospholipids
shipped in
dry ice
storage temp.
−20°C
SMILES string
[H][C@@](COP([O-])(O[C@H]1[C@H](O)[C@@H](OP(O)([O-])=O)[C@H](OP([O-])(O)=O)[C@@H](O)[C@H]1O)=O)(OC(CCCCCCC)=O)COC(CCCCCCC)=O.[NH4+].[NH4+].[NH4+]
InChI
1S/C25H49O19P3.3H3N/c1-3-5-7-9-11-13-18(26)39-15-17(41-19(27)14-12-10-8-6-4-2)16-40-47(37,38)44-23-20(28)21(29)24(42-45(31,32)33)25(22(23)30)43-46(34,35)36;;;/h17,20-25,28-30H,3-16H2,1-2H3,(H,37,38)(H2,31,32,33)(H2,34,35,36);3*1H3/t17-,20-,21+,22+,23-,24-
InChI key
FRWPUPUJRUQWKA-OZTQGENFSA-N
General description
Although PI(4,5)P2 is a minor component of cell membranes, it plays a critical role as a substrate for a number of important signaling proteins. PI(4,5)P2 is an intermediate in the IP3/DAG pathway where it is hydrolyzed by phospholipase C to liberate the second messengers, inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). PI(4,5)P2 is also a substrate for PI 3-kinase where it is phosphorylated to PI(3,4,5)P3, an activator of downstream signaling components such as the protein kinase AKT. The dioctanoyl derivative of PI(4,5)P2 is more water soluble than its long chain counterparts.
Application
08:0 PI(4,5)P2 is suitable for use to identify its binding site in transient receptor potential vanilloid 4 (TRPV4 N) terminus. It has been used in in vitro binding assay to determine the binding of G-protein coupled receptor kinases (GRKs) and β2-adrenergic receptor (β2AR).
Packaging
2 mL Amber Serum Vial with Stopper and Crimp Cap (850185P-100ug)
2 mL Amber Serum Vial with Stopper and Crimp Cap (850185P-500ug)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
저장 등급
11 - Combustible Solids