1.01900
Dimethyl sulfoxide
for headspace gas chromatography SupraSolv®
동의어(들):
Methanesulfinylmethane, Methyl sulfoxide, Dimethyl(oxido)sulfur, DMSO, DMSO
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제품정보 (DICE 배송 시 비용 별도)
Linear Formula:
(CH3)2SO
CAS 번호:
Molecular Weight:
78.13
UNSPSC Code:
12191502
NACRES:
NA.03
EC Index Number:
200-664-3
MDL number:
Beilstein/REAXYS Number:
506008
Assay:
≥99.8% (GC)
Technique(s):
GC-HS: suitable
Bp:
189 °C (lit.)
Vapor pressure:
0.42 mmHg ( 20 °C)
Quality Segment
agency
according to Ph. Eur., according to USP
vapor density
2.7 (vs air)
vapor pressure
0.42 mmHg ( 20 °C)
product line
SupraSolv®
assay
≥99.8% (GC)
form
liquid
autoignition temp.
573 °F
potency
28300 mg/kg LD50, oral (Rat), 40000 mg/kg LD50, skin (Rat)
expl. lim.
42 %, 63 °F
technique(s)
GC-HS: suitable
impurities
≤1 μg/g Every residual solvent of class 1 acc. to ICH, ≤10 μg/g Every residual solvent of class 2 acc. to ICH, ≤50 μg/g Every residual solvent of class 3 acc. to ICH, ≤0.05% Water
evapn. residue
≤3.0 mg/L
color
APHA: ≤10
refractive index
n20/D 1.479 (lit.)
kinematic viscosity
2.14 cSt
bp
189 °C (lit.)
mp
16-19 °C (lit.)
transition temp
flash point 87 °C
density
1.10 g/mL (lit.)
storage temp.
2-30°C
SMILES string
CS(C)=O
InChI
1S/C2H6OS/c1-4(2)3/h1-2H3
InChI key
IAZDPXIOMUYVGZ-UHFFFAOYSA-N
General description
SupraSolv® for headspace gas chromatography (GC-HS) is a dedicated high-purity solvent grade specifically formulated to meet the stringent analytical demands of residual solvent determination in pharmaceutical active pharmaceutical ingredients (APIs), drug products, and other regulated matrices.In headspace GC, the solvent serves as the diluent medium in which the sample is dissolved prior to equilibrium partitioning of volatile analytes into the gaseous headspace phase for subsequent chromatographic injection. Consequently, the chemical purity of the solvent is of critical analytical importance: any residual volatile impurities intrinsic to the solvent matrix may co-elute with target analytes, generating false-positive signals or suppressing accurate quantification. SupraSolv® headspace solvents are therefore specifically developed and tested to contain extremely low concentrations of residual solvents, as mandated by regulatory guidelines.
Application
SupraSolv® headspace GC solvents are indispensable in pharmaceutical residual solvent testing, polymer and excipient quality control, food packaging safety assessment, and industrial material characterization — analytical contexts in which solvent purity is a direct regulatory and safety requirement, and where the integrity of trace-level volatile quantification is non-negotiable.
Features and Benefits
- Regulatory compliance with ICH Q3C, Ph. Eur., and USP residual solvent guidelines, directly supporting pharmaceutical quality control workflows
- Ultra-low intrinsic volatile impurity content, eliminating solvent-derived interferences in the headspace chromatogram and ensuring an unobstructed baseline
- Batch-to-batch consistency, ensuring reproducibility across analytical campaigns
Analysis Note
SupraSolv® headspace solvents adhere to the residual solvent classification thresholds defined by the International Council for Harmonisation (ICH Q3C) and referenced in pharmacopoeial standards (Ph. Eur. and USP), with certified limits including:
- Class 1 solvents (known human carcinogens / environmental hazards): ≤ 1 µg/g
- Class 2 solvents (non-genotoxic, dose-dependent toxicants): ≤ 10 µg/g
- Class 3 solvents (low toxic potential): ≤ 50 µg/g
Other Notes
Explore various lab safety accessories and equipment for safe handling of solvents to increase your safety level from the first usage.
Legal Information
SUPRASOLV is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Supercools easily and remelts slowly at room temperature. Solidified product can be re-liquified by warming to room temperature without detriment to the product.
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저장 등급
10 - Combustible liquids
flash_point_f
188.6 °F - closed cup
flash_point_c
87 °C - closed cup
시험 성적서(COA)
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