Dimethyl sulfoxide

SupraSolv solvents for headspace gas chromatography are developed particularly for the analysis of residual
solvents in drug substances, excipients and drug products according to ICH, Ph Eur and USP - SupraSolv headspace solvents are tested for all
residual solvents defined by the ICH.

DMSO can be used as an effective solvent for dissolving a wide range of polar and non-polar compounds for sample preparation in HS-GC. Its high polarity allows for the extraction of volatile organic compounds (VOCs) from complex matrices, such as biological samples or environmental matrices. DMSO also enhances the volatility of certain compounds, facilitating their detection in HS-GC. By modifying the physical properties of the analytes, DMSO helps in achieving better separation and sensitivity during the chromatographic analysis.

Saturation Concentration in Air: 8.0 g/m3 (20 °C)

Purity (GC): ≥ 99.8 %
Identity (IR): conforms
Evaporation residue: ≤ 3.0 mg/l
Water: ≤ 0.05 %
Color: ≤ 10 Hazen
GC/HS (Every residual solvent of class 1acc. ICH): ≤ 1 µg/g
GC/HS (Every residual solvent of class 2acc. ICH): ≤ 10 µg/g
GC/HS (Every residual solvent of class 3acc. ICH): ≤ 50 µg/g
Suitable as solvent for the analysis of residual solvents of ICH classes 1,2 and 3 according to Ph Eur and USP.
Formic acid, acetic acid, dimethylacetamide and cumene are not detected.

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SUPRASOLV is a registered trademark of Merck KGaA, Darmstadt, Germany

Supercools easily and remelts slowly at room temperature. Solidified product can be re-liquified by warming to room temperature without detriment to the product.