212385-M
Carbamoylcholine chloride
≥98% (titration), nicotinic and muscarinic receptor agonist, solid (fine crystalline)
동의어(들):
Carbachol, Carbamoylcholine Chloride
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제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C6H15ClN2O2
CAS 번호:
Molecular Weight:
182.65
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (titration)
Form:
solid (fine crystalline)
Storage condition:
OK to freeze, desiccated (hygroscopic)
제품 이름
Carbachol, An unsubstituted carbamoyl ester that acts as an agonist for nicotinic and muscarinic acetylcholine receptors.
Quality Segment
description
Merck USA index - 14, 1779
assay
≥98% (titration)
form
solid (fine crystalline)
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic)
color
white
solubility
methanol: 100 mg/mL, water: 100 mg/mL, ethanol: 20 mg/mL
storage temp.
10-30°C
SMILES string
Cl.[N+](CCO\C(=N\[H])\[O-])(C)(C)C
InChI
1S/C6H14N2O2.ClH/c1-8(2,3)4-5-10-6(7)9;/h4-5H2,1-3H3,(H-,7,9);1H
InChI key
AIXAANGOTKPUOY-UHFFFAOYSA-N
General description
An unsubstituted carbamoyl ester that acts as an agonist for nicotinic and muscarinic acetylcholine receptors. Known to increase cytosolic Ca2+ and InsP3 and decrease cAMP levels. Resistant to the action of acetylcholine esterase (AChE) and non-specific cholinesterases. Inhibits apoptotic death of cultured granule neurons.
Biochem/physiol Actions
Primary Target
Agonist for nicotinic and muscarinic acetylcholine receptors
Agonist for nicotinic and muscarinic acetylcholine receptors
Preparation Note
Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.
Other Notes
Jence, M., et al. 1995. J. Neurochem. 64, 1605.
Yan, G.M., et al. 1995. Mol. Pharmacol. 47, 248.
Mangels, L.A., and Gnegy, M.E. 1992. J. Biol. Chem.267, 5847.
Watanabe, A.M., et al. 1992. In Basic and Clinical Pharmacology, Fifth Edition Katzung, B.G. ed.) Appleton and Lange, Norwalk, CT, p. 82.
Howe, P.H., et al. 1986. J. Pharmacol. Exp. Ther.239, 574.
Yan, G.M., et al. 1995. Mol. Pharmacol. 47, 248.
Mangels, L.A., and Gnegy, M.E. 1992. J. Biol. Chem.267, 5847.
Watanabe, A.M., et al. 1992. In Basic and Clinical Pharmacology, Fifth Edition Katzung, B.G. ed.) Appleton and Lange, Norwalk, CT, p. 82.
Howe, P.H., et al. 1986. J. Pharmacol. Exp. Ther.239, 574.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Highly Toxic (H)
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signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 2 Oral
저장 등급
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable