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239765

Cycloheximide

Name: Cycloheximide
Brand: MM

hFKBP12 inhibitor, solution

동의어(들):

InSolution Cycloheximide

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제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₁₅H₂₃NO₄

CAS 번호:

66-81-9

Molecular Weight:

281.35

UNSPSC Code:

12352111

NACRES:

NA.77

MDL number:

MFCD00082346

Form:

solution

Quality level:

100

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제품 이름

Cycloheximide, InSolution, 100 mg/mL in DMSO, Suitable for cell culture

Quality Level

100

form

solution

manufacturer/tradename

Calbiochem^®

concentration

100 mg/mL in DMSO

solubility

DMSO: soluble

storage temp.

2-8°C

SMILES string

N1C(=O)CC(CC1=O)C[C@@H](O)[C@@H]2C[C@H](C[C@@H](C2=O)C)C

InChI

1S/C15H23NO4/c1-8-3-9(2)15(20)11(4-8)12(17)5-10-6-13(18)16-14(19)7-10/h8-12,17H,3-7H2,1-2H3,(H,16,18,19)/t8-,9-,11-,12+/m0/s1

InChI key

YPHMISFOHDHNIV-FSZOTQKASA-N

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General description

A convenient ready-to-use form of Cycloheximide (Cat. No. 239763). An anti-fungal antibiotic that inhibits protein synthesis in eukaryotes but not in prokaryotes. Interacts directly with the translocase enzyme, interfering with the translocation step. Also inhibits cell-free protein synthesis in eukaryotes. Competitively inhibits hFKBP12 (K_i = 3.4 µM). Triggers apoptosis in HL-60 cells, T-cell hybridomas, Burkitt′s lymphoma cells, and a variety of other cell types, including rodent macrophages. Induces DNA fragmentation in macrophages, but inhibits DNA cleavage in rat thymocytes treated with thapsigargin, methylprednisolone, and ionomycin. Rapidly destroyed in alkaline solutions.

Biochem/physiol Actions

Primary Target
hFKBP12

Packaging

Packaged under inert gas

Physical form

A 100 mg/ml solution of Cycloheximide (Cat. No. 239763 ) in DMSO (sterile-filtered).

Preparation Note

Following initial use, aliquot and refrigerate (4°C).

Other Notes

Christner, C., et al. 1999. J. Med. Chem.42, 3615.
Lu, Q. and Mellgreen,R.L. 1996. Arch. Biochem. Biophys.334, 175.
Chow, S.C., et al. 1995. Exp. Cell Res.216, 149.
Waring, P. 1990. J. Biol. Chem.265, 14476.
Obrig, T.G., et al. 1971. J. Biol. Chem.246, 174.
Pestka, S. 1971. Annu. Rev. Microbiol.25, 487.

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Highly Toxic & Carcinogenic / Teratogenic (I)

pictograms

GHS06,GHS08

signalword

Danger

hcodes

H301,H341,H360D,H412

pcodes

P202 - P264 - P270 - P273 - P280 - P301 + P310

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Chronic 3 - Muta. 2 - Repr. 1B

저장 등급

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

시험 성적서(COA)

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SKU	GTIN
239765-1MLCN	04055977216783

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