227056
N,N-Dimethylformamide
anhydrous, 99.8%
동의어(들):
DMF, NSC 5356
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제품정보 (DICE 배송 시 비용 별도)
Linear Formula:
HCON(CH3)2
CAS 번호:
Molecular Weight:
73.09
UNSPSC Code:
12352111
NACRES:
NA.21
PubChem Substance ID:
EC Number:
200-679-5
Beilstein/REAXYS Number:
605365
MDL number:
eCl@ss:
39031202
Assay:
99.8%
Form:
liquid
grade
anhydrous
Quality Segment
vapor density
2.5 (vs air)
vapor pressure
2.7 mmHg ( 20 °C)
assay
99.8%
form
liquid
autoignition temp.
833 °F
expl. lim.
15.2 %
impurities
<0.005% water
evapn. residue
<0.0005%
refractive index
n20/D 1.430 (lit.)
pH
7 (20 °C, 200 g/L)
bp
153 °C (lit.)
mp
−61 °C (lit.)
density
0.944 g/mL (lit.)
SMILES string
[H]C(=O)N(C)C
InChI
1S/C3H7NO/c1-4(2)3-5/h3H,1-2H3
InChI key
ZMXDDKWLCZADIW-UHFFFAOYSA-N
General description
N,N-Dimethylformamide (DMF) is the commonly employed solvent for chemical reactions. DMF is a useful solvent employed for the isolation of chlorophyll from plant tissues. It is widely employed reagent in organic synthesis. It plays multiple roles in various reactions such as solvent, dehydrating agent, reducing agent as well as catalyst. It is a multipurpose building block for the synthesis of compounds containing O, -CO, -NMe2, -CONMe2, -Me, -CHO as functional groups.
N,N-Dimethylformamide is a polar solvent commonly used in organic synthesis. It also acts as a multipurpose precursor for formylation, amination, aminocarbonylation, amidation and cyanation reactions.
Application
Solvent for many hydrophobic organic compounds.
N,N-Dimethylformamide (anhydrous) has been used as solvent for the synthesis of cytotoxic luteinizing hormone-releasing hormone (LH-RH) conjugate AN-152 (a chemotherapeutic drug) and fluorophore C625 [4-(N,N-diphenylamino)-4′-(6-O-hemiglutarate)hexylsulfinyl stilbene]. It may be employed as solvent medium for the various organic reduction reactions.
DMF has been used as a solvent in the following processes:
- Multi-step synthesis of L-azidohomoalanine (L-Aha) during the substitution of the mesylate by sodium azide.
- Synthesis of phosphine-FLAG®, a detection reagent for metabolic labeling of glycans.
- Synthesis of per-O-acetylated 6-azidofucose, a per-O-acetylated azido sugar.
Packaging
Legal Information
FLAG is a registered trademark of Merck KGaA, Darmstadt, Germany
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Danger
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Eye Irrit. 2 - Flam. Liq. 3 - Repr. 1B
저장 등급
3 - Flammable liquids
flash_point_f
135.5 °F - closed cup
flash_point_c
57.5 °C - closed cup
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter