A2942

Amphotericin B

Name: Amphotericin B
Brand: SIGMA

solution, suitable for cell culture, BioReagent

동의어(들):

Amphotericin, Fungizone

조직 및 계약 가격을 보려면 로그인를 클릭합니다.

크기 선택

제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₄₇H₇₃NO₁₇

CAS 번호:

1397-89-3

Molecular Weight:

924.08

UNSPSC Code:

12352207

PubChem Substance ID:

24890711

NACRES:

NA.76

MDL number:

MFCD00877763

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제품 이름

Amphotericin B solution, 250 μg/mL in deionized water, 0.1 μm filtered, BioReagent, suitable for cell culture

SMILES string

[H][C@]12C[C@@H](O[C@@H]3O[C@H](C)[C@@H](O)[C@H](N)[C@@H]3O)\C=C\C=C\C=C\C=C\C=C\C=C\C=C\[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]1C(=O)O[Na])O2

InChI key

APKFDSVGJQXUKY-INPOYWNPSA-N

InChI

1S/C47H73NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-34(64-46-44(58)41(48)43(57)30(4)63-46)24-38-40(45(59)60)37(54)26-47(61,65-38)25-33(51)22-36(53)35(52)20-19-31(49)21-32(50)23-39(55)62-29(3)28(2)42(27)56/h5-18,27-38,40-44,46,49-54,56-58,61H,19-26,48H2,1-4H3,(H,59,60)/b6-5+,9-7+,10-8+,13-11+,14-12+,17-15+,18-16+/t27-,28-,29-,30+,31+,32+,33-,34-,35+,36+,37-,38-,40+,41-,42+,43+,44-,46-,47+/m0/s1

sterility

0.1 μm filtered

product line

BioReagent

form

liquid

concentration

250 μg/mL in deionized water

technique(s)

cell culture | mammalian: suitable

color

yellow

antibiotic activity spectrum

fungi, yeast

mode of action

cell membrane | interferes

shipped in

dry ice

storage temp.

−20°C

Quality Level

200

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General description

Amphotericin B is a macrocyclic lactone with a hydrophilic polyhydroxyl chain and a lipophilic polyene based hydrocarbon chain.

Application

Amphotericin B solution has been used:

as an intraperitoneal injection for the treatment of Aspergillus fumigatus infection in mice
as a constituent of aspiration medium for the culture of Chinese Merino ewe ovaries
as a constituent of transport medium during the collection of equine corpora lutea
as a supplement in RPMI medium for the culture of the mouse-mouse B cell hybridoma 55-6 cell line

Biochem/physiol Actions

Amphotericin B is a polyene antifungal antibiotic from Streptomyces sp. that is clinically used to treat systemic fungal infections. It has a high affinity for sterols, especially ergosterols, of both fungal and bacterial cell membranes. Normal usage in maintenance of antifungal cell cultures is 2.5 mg/L with penicillin and streptomycin used in the medium.

Amphotericin B is most effective against fungi and yeast. It forms transmembrane channels by binding to sterols associated with membranes, thereby leading to the leakage of small molecules. Amphotericin B elicits toxicity despite being an effective antibiotic for treating mycoses.

Packaging

20,50,100ml

Preparation Note

It is not unusual for this material to form a precipitate in aqueous solutions. Mixing the solution will redissolve most of the precipitate but, if it does not fully resolubilize, the Amphotericin B will still be suitable for use.

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Light sensitive.

This product is supplied as 250 μg/mL Amphotericin B in deionized water. It is a solution containing Amphotericin B, and the following components aimed to improve its solubility: sodium deoxycholate, sodium chloride and sodium phosphate.

Disclaimer

Amphotericin B remains active for 3 days in culture at 37°C.

저장 등급

12 - Non Combustible Liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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문서 라이브러리 방문

A newly identified derivative of amphotericin B: isolation, structure determination and primary evaluation of the activity and toxicity.

Yong-Hong Wang et al.

The Journal of antibiotics, 63(9), 553-557 (2010-07-08)

A new derivative of amphotericin B named amphotericin B(5) has been obtained under the following condition: amphotericin B powder was first dissolved in N,N-dimethylformamide at room temperature to obtain a solution of concentration of 2.0 mg ml(-1). Then, the solution

Analysis of kinetic, stoichiometry and regulation of glucose and glutamine metabolism in hybridoma batch cultures using logistic equations.

María Lourdes Acosta et al.

Cytotechnology, 54(3), 189-200 (2008-11-13)

Batch cultures were carried out to study the kinetic, stoichiometry, and regulation of glucose and glutamine metabolism of a murine hybridoma line. Asymmetric logistic equations (ALEs) were used to fit total and viable cell density, and nutrient and metabolite/product concentrations.

One-sided action of amphotericin B on cholesterol-containing membranes is determined by its self-association in the medium.

J Bolard et al.

Biochemistry, 30(23), 5707-5715 (1991-06-11)

The inducement of K+ permeability through membranes by the polyene antibiotic amphotericin B (AmB) has been analyzed as a measure of the antibiotic activity. Dose-response curves have been obtained with cholesterol- and ergosterol-containing egg yolk phosphatidylcholine large unilamellar vesicles (LUVs)

Thymosin alpha 1 activates dendritic cells for antifungal Th1 resistance through toll-like receptor signaling.

Luigina Romani et al.

Blood, 103(11), 4232-4239 (2004-02-26)

Dendritic cells (DCs) show a remarkable functional plasticity in the recognition of Aspergillus fumigatus and orchestrate the antifungal immune resistance in the lungs. Here, we show that thymosin alpha 1, a naturally occurring thymic peptide, induces functional maturation and interleukin-12

Xenotransplantation of canine spermatogonial stem cells (cSSCs) regulated by FSH promotes spermatogenesis in infertile mice.

Naira Caroline Godoy Pieri et al.

Stem cell research & therapy, 10(1), 135-135 (2019-05-22)

Xenotransplantation of spermatogonial stem cells (SSCs) has become a popular topic in various research fields because manipulating these cells can provide insights into the mechanisms associated with germ cell lines and the entire spermatogenesis process; moreover, these cells can be

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Amphotericin B

solution, suitable for cell culture, BioReagent

크기 선택

제품정보 (DICE 배송 시 비용 별도)

주요 문서

속성

제품 이름

SMILES string

InChI key

InChI

sterility

product line

form

concentration

technique(s)

color

antibiotic activity spectrum

mode of action

shipped in

storage temp.

Quality Level

관련 카테고리

설명

General description

Application

Biochem/physiol Actions

Packaging

Preparation Note

Other Notes

Disclaimer

안전성 정보

저장 등급

flash_point_f

flash_point_c

ppe

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