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A8674

Antimycin A

Name: Antimycin A
Brand: SIGMA

from Streptomyces sp., mitochondrial electron transport chain complex III inhibitor, powder

동의어(들):

Antipiricullin

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제품정보 (DICE 배송 시 비용 별도)

CAS 번호:

1397-94-0

UNSPSC Code:

12352200

PubChem Substance ID:

24891355

NACRES:

NA.77

MDL number:

MFCD01779723

Form:

powder

Quality level:

300

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속성

제품 이름

Antimycin A from Streptomyces sp.,

form

powder

Quality Level

300

antibiotic activity spectrum

fungi

mode of action

enzyme | inhibits

storage temp.

−20°C

SMILES string

[H]C(=O)Nc1cccc(C(=O)N[C@H]2[C@@H](C)OC(=O)C(CCCCCC)[C@@H](OC(=O)CC(C)C)[C@H](C)OC2=O)c1O

InChI

1S/C28H40N2O9/c1-6-7-8-9-11-20-25(39-22(32)14-16(2)3)18(5)38-28(36)23(17(4)37-27(20)35)30-26(34)19-12-10-13-21(24(19)33)29-15-31/h10,12-13,15-18,20,23,25,33H,6-9,11,14H2,1-5H3,(H,29,31)(H,30,34)/t17-,18+,20?,23+,25+/m1/s1

InChI key

UIFFUZWRFRDZJC-RBVQMQRASA-N

설명

General description

Antimycin is an antibiotic produced by Streptomyces species. It inhibits mitochondrial electron transport chain complex III and favors reactive oxygen species (ROS) production, impairing mitochondrial depolarization. It inhibits nitric oxide-mediated apoptosis and modulatescytochrome C release. It suppresses tumorigenesis in lung cancer cells and could be a potential therapeutic agent.Antimycin A serves as a positive control for superoxide generation.

Chemical structure: peptide

Application

Antimycin A from Streptomyces sp. has been used:

as a respiratory chain inhibitor in neuronal cultures
in organello ATP production assay in Trypanosoma brucei cells
in respiration assay for papillary thyroid carcinoma (PTC) cell lines

Antimycin A has been used to study the specific sites of reactive oxygen species production in mitochondria isolated from skeletal muscle of chronic obstructive pulmonary disease patients, and its relationship with local oxidative stress induced by exercise