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C2505

Corticosterone

Name: Corticosterone
Brand: SIGMA

≥92% (HPLC), powder, corticosteroid hormone

동의어(들):

11β,21-Dihydroxy-4-pregnene-3,20-dione, 11β,21-Dihydroxyprogesterone, 4-Pregnene-11β,21-diol-3,20-dione, Kendall’s Compound B, Reichstein’s Substance H

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제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₂₁H₃₀O₄

CAS 번호:

50-22-6

Molecular Weight:

346.46

NACRES:

NA.77

PubChem Substance ID:

24278302

UNSPSC Code:

51111800

EC Number:

200-019-6

MDL number:

MFCD00037715

Beilstein/REAXYS Number:

2339601

Assay:

≥92%

Form:

powder

Quality level:

200

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속성

제품 이름

Corticosterone, ≥92%

biological source

synthetic (organic)

Quality Level

200

assay

≥92%

form

powder

mp

179-183 °C (lit.)

solubility

chloroform: 50 mg/mL, clear, colorless to faintly yellow

shipped in

ambient

storage temp.

room temp

SMILES string

C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CC[C@@H]2C(=O)CO

InChI

1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1

InChI key

OMFXVFTZEKFJBZ-HJTSIMOOSA-N

Gene Information

human ... EBP(10682), SERPINA6(866)
rat ... Ar(24208), Nr3c1(24413)

설명

Application

Corticosterone has been used:

in chronic treatment to investigate its effect on somatostatin (SST) neurons in mice
as a stress inducing hormone in pregnant mice
to test its effect on depression-related behaviors in mice

Biochem/physiol Actions

Corticosterone is synthesized from 11-deoxycortisone by the action of enzyme 11β-hydroxylase majorly in adrenal glands. However, it may also be synthesized in non-adrenal tissues including leydig cells of testes and in murine thymus. Corticosterone is released post activation of hypothalamus-pituitary-adrenal (HPA) axis. It is a key player regulating metabolism, immune function and response to stress. It is produced by HPA activation in response to stress in myeloid cells. Elevated levels of corticosterone is observed in Huntington′s disease (HD).

Corticosterone is a glucocorticoid secreted by the adrenal cortex that activates both mineralocorticoid and glucocorticoid receptors.

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저장 등급

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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