C7698
Cycloheximide
from microbial, ≥94% (TLC)
동의어(들):
3-[2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]glutarimide, Actidione, Naramycin A
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C15H23NO4
CAS 번호:
Molecular Weight:
281.35
UNSPSC Code:
12352111
NACRES:
NA.77
PubChem Substance ID:
EC Number:
200-636-0
Beilstein/REAXYS Number:
88868
MDL number:
InChI
1S/C15H23NO4/c1-8-3-9(2)15(20)11(4-8)12(17)5-10-6-13(18)16-14(19)7-10/h8-12,17H,3-7H2,1-2H3,(H,16,18,19)/t8-,9-,11-,12+/m0/s1
SMILES string
[H][C@]1(C[C@@H](C)C[C@H](C)C1=O)[C@H](O)CC2CC(=O)NC(=O)C2
InChI key
YPHMISFOHDHNIV-FSZOTQKASA-N
biological source
microbial
assay
≥94% (TLC)
form
powder
color
white to off-white
solubility
ethanol: soluble, clear to hazy
antibiotic activity spectrum
fungi, yeast
mode of action
protein synthesis | interferes
storage temp.
2-8°C
Quality Level
Gene Information
human ... FKBP1A(2280), PIN1(5300)
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관련 카테고리
Application
- In yeast strains, cycloheximide has been used as a protein synthesis inhibitor in the cycloheximide chase experiment.
- It has been used to inhibit translation in mammalian cells.
- It has been used to suppress fungal growth.
Biochem/physiol Actions
Mode of Action: Translation inhibition in eukaryotes resulting in cell growth arrest and cell death. CHX is widely used for the selection of CHX-resistant strains of yeast and fungi, controlled inhibition of protein synthesis for detection of short-lived proteins and super-induction of protein expression, and apoptosis induction or facilitation of apoptosis induction by death receptors.
Activity Spectrum: Active against yeast and fungi like Candida, Aspergillus, Saccharomyces, Penicillium
Activity Spectrum: Active against yeast and fungi like Candida, Aspergillus, Saccharomyces, Penicillium
Features and Benefits
- High-quality antibiotic suitable for multiple research applications
- Commonly used in Cell Biology and Biochemical applications
General description
Cycloheximide, also known as Actidione, is a glutarimide antibiotic commonly derived from the bacterium Streptomyces griseus. It acts as a potent inhibitor of protein biosynthesis in eukaryotic cells by disrupting the translocation step during translation, effectively blocking translational elongation. In microbiology, it plays a crucial role as a selection agent for resistant strains of yeast and fungi, proving invaluable in controlled experimental environments.
In cell biology and biochemical research, Cycloheximide showcases a dual nature concerning Apoptosis Induction, inducing or inhibiting apoptosis depending on the cell type. Its rapid and reversible effects make it an ideal choice for studying cellular processes and determining protein half-life. Cycloheximide also finds extensive applications in biomedical research, where it inhibits protein synthesis in eukaryotic cells studied in vitro (outside of organisms) and its effects are rapidly reversed by simply removing it. This makes Cycloheximide a go-to choice for exploring cell biology, biomedical and biochemical research, offering precise control and versatility in experiments.
In cell biology and biochemical research, Cycloheximide showcases a dual nature concerning Apoptosis Induction, inducing or inhibiting apoptosis depending on the cell type. Its rapid and reversible effects make it an ideal choice for studying cellular processes and determining protein half-life. Cycloheximide also finds extensive applications in biomedical research, where it inhibits protein synthesis in eukaryotic cells studied in vitro (outside of organisms) and its effects are rapidly reversed by simply removing it. This makes Cycloheximide a go-to choice for exploring cell biology, biomedical and biochemical research, offering precise control and versatility in experiments.
Other Notes
For additional information on our range of Biochemicals, please complete this form.
Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.
Preparation Note
Tightly closed. Dry. Keep in a well-ventilated place. Keep locked up or in an area accessible
only to qualified or authorized persons.
only to qualified or authorized persons.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 2 Oral - Aquatic Chronic 2 - Muta. 2 - Repr. 1B
저장 등급
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
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