E9750

Estrone

Name: Estrone
Brand: SIGMA

≥99% (HPLC), powder, estrogen receptor agonist

동의어(들):

1,3,5(10)-Estratrien-3-ol-17-one, 3-Hydroxy-1,3,5(10)-estratrien-17-one, Folliculin

조직 및 계약 가격을 보려면 로그인를 클릭합니다.

크기 선택

제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₁₈H₂₂O₂

CAS 번호:

53-16-7

Molecular Weight:

270.37

NACRES:

NA.77

PubChem Substance ID:

24278427

UNSPSC Code:

51111800

EC Number:

200-164-5

MDL number:

MFCD00003620

Beilstein/REAXYS Number:

1915077

Assay:

≥99%

Form:

powder

Quality level:

200

주요 문서

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제품 이름

Estrone, ≥99%

InChI key

DNXHEGUUPJUMQT-CBZIJGRNSA-N

InChI

1S/C18H22O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-16,19H,2,4,6-9H2,1H3/t14-,15-,16+,18+/m1/s1

SMILES string

C[C@]12CC[C@H]3[C@@H](CCc4cc(O)ccc34)[C@@H]1CCC2=O

biological source

synthetic (organic)

sterility

non-sterile

assay

≥99%

form

powder

mp

258-260 °C (lit.)

solubility

dioxane: 50 mg/mL, clear, colorless to very faintly yellow

shipped in

ambient

storage temp.

room temp

Quality Level

200

Gene Information

human ... ESR1(2099), ESR2(2100), ESRRA(2101), ESRRB(2103), HSD17B1(3292), SERPINA6(866)
mouse ... Esr1(13982)
rat ... Esr1(24890)

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General description

Estrone is a weak form of estrogen and exists as estrone sulphate. Estrone is a luteolytic estrogen produced by the corpus luteum. In the follicle, estrone is synthesized from androstenedione by the action of cytochrome P450 aromatase.

Application

Estrone has been used:

as medium supplement for hormone based degranulation studies of natural killer cells
as an endocrine disrupting compound for screening bacterial biosensor in toxic water.
as medium component for monitoring fatty acid synthase (FASN) activity in breast adenocarcinoma cell lines

Biochem/physiol Actions

Estrone is an agonist for the estrogen receptor. The estradiol to estrone interconversion is favourable in menopause. Oral hormone replacement therapy (HRT) of estradiol-17β increases circulating levels of estrone.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

pictograms

GHS08

signalword

Danger

hcodes

H351,H360FD,H362

pcodes

P202 - P260 - P263 - P264 - P280 - P308 + P313

Hazard Classifications

Carc. 2 - Lact. - Repr. 1A

저장 등급

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

가장 최신 버전 중 하나를 선택하세요:

시험 성적서(COA)

Lot/Batch Number

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문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

The molecular control of corpus luteum formation, function, and regression

Stocco C, et al.

Endocrine Reviews, 28(1), 117-149 (2007)

Pharmacology of estrogens and progestogens: influence of different routes of administration

Kuhl H

Climacteric : The Journal of the International Menopause Society, 8(1), 3-63 (2005)

Estrone-a partial estradiol antagonist in the normal breast

Lundstrom E, et al.

Gynecological Endocrinology, 31(9), 747-749 (2015)

Hormone replacement with estradiol: conventional oral doses result in excessive exposure to estrone

Friel PN, et al.

Alternative Medicine Review, 10(1), 36-42 (2005)

Creation of a new portable biosensor for water toxicity determination

Eltzov E, et al.

Sensors and Actuators B, Chemical, 221(9), 1044-1054 (2015)

모든 관련된 서류 보기

문서

Discover Bioactive Small Molecules for ADME/Tox

Estrone

≥99% (HPLC), powder, estrogen receptor agonist

크기 선택

제품정보 (DICE 배송 시 비용 별도)

주요 문서

속성

제품 이름

InChI key

InChI

SMILES string

biological source

sterility

assay

form

mp

solubility

shipped in

storage temp.

Quality Level

Gene Information

관련 카테고리

설명

General description

Application

Biochem/physiol Actions

Features and Benefits

안전성 정보

pictograms

signalword

hcodes

pcodes

Hazard Classifications

저장 등급

wgk

flash_point_f

flash_point_c

ppe

문서

시험 성적서(COA)

이 제품을 이미 가지고 계십니까?

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