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P0884

(±)-Propranolol hydrochloride

Name: (±)-Propranolol hydrochloride
Brand: SIGMA

≥99% (TLC), powder, β-adrenoceptor antagonist

동의어(들):

(±)-1-Isopropylamino-3-(1-naphthyloxy)-2-propanol hydrochloride, DL-Propranolol hydrochloride

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제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₁₆H₂₁NO₂ · HCl

CAS 번호:

318-98-9

Molecular Weight:

295.80

NACRES:

NA.77

PubChem Substance ID:

24277796

UNSPSC Code:

12352200

EC Number:

206-268-7

MDL number:

MFCD00012558

Beilstein/REAXYS Number:

4164259

Assay:

≥99% (TLC)

Form:

powder

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속성

제품 이름

(±)-Propranolol hydrochloride, ≥99% (TLC), powder

Quality Segment

200

assay

≥99% (TLC)

form

powder

color

white

solubility

ethanol: 10 mg/mL, DMSO: <14.5 mg/mL, H₂O: 50 mg/mL, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 8.0 mg/mL

originator

AstraZeneca

storage temp.

2-8°C

SMILES string

Cl.CC(C)NCC(O)COc1cccc2ccccc12

InChI

1S/C16H21NO2.ClH/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16;/h3-9,12,14,17-18H,10-11H2,1-2H3;1H

InChI key

ZMRUPTIKESYGQW-UHFFFAOYSA-N

Gene Information

human ... ADRB1(153), ADRB2(154), ADRB3(155), HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355), HTR2A(3356), HTR2B(3357), HTR2C(3358)

설명

General description

Propranolol hydrochloride is easily soluble in ethanol and water.

dissolve with heat. Aqueous solutions are most stable at pH 3.0 and decompose rapidly at basic pH. Decomposition is accompanied by discoloration of the solution.

Application

(±)-Propranolol hydrochloride has been used:

to determine whether autonomic nervous system mediated the promotive effect on skin microcirculation in rat
as a non-selective β- receptor blocker to reduce the arrhythmogenic events
to study its effect on oxygen-induced retinopathy in mice

Biochem/physiol Actions

Propranolol hydrochloride is a β-adrenoceptor antagonist. Its action at β2 receptor results in bronchoconstriction. Due to its lipophilic nature, propranolol can penetrate to the central nervous system and has a negative effect. It serves as a 5-HT₁/5-HT₂ serotonin receptor antagonist. Propranolol hydrochloride is useful as an antihypertensive drug, cardiac depressant and also in the treatment of angina pectoris. It decreases the effect of stress and exercise on heart by reducing the rate of contraction and conduction of impulse. It is known to competitively block the action of catecholamines.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Disclaimer

Shelf-life of the solid is at least four years if stored protected from the uptake of moisture.

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pictograms

GHS07

signalword

Warning

hcodes

H302

pcodes

P264 - P270 - P301 + P312 + P330 - P501

Hazard Classifications

Acute Tox. 4 Oral

저장 등급

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c