P2443
Pluronic® F-127
powder, BioReagent, suitable for cell culture
동의어(들):
Non-ionic copolymer surfactant
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제품정보 (DICE 배송 시 비용 별도)
Linear Formula:
(C3H6O·C2H4O)x
CAS 번호:
UNSPSC Code:
12161902
PubChem Substance ID:
NACRES:
NA.75
MDL number:
Quality Segment
description
Non-ionic, contains 100ppm BHT
product line
BioReagent
form
powder
mol wt
~12600 g/mol
technique(s)
cell culture | mammalian: suitable
CMC
950-1000 ppm (~25°C)
transition temp
cloud point >100 °C
HLB
18 - 23
SMILES string
O2C(C2)C.O1CC1
InChI
1S/C3H6O.C2H4O/c1-3-2-4-3;1-2-3-1/h3H,2H2,1H3;1-2H2
InChI key
RVGRUAULSDPKGF-UHFFFAOYSA-N
General description
Pluronicpluronic® F-127, also known as poloxamer 407, is a non-toxic and nonionic copolymer. It contains polyethylene oxide-polypropylene oxide arranged in a triblock structure to form PEO-PPO-PEO symmetric. Surfactant properties of this polymer derived from its amphiphilic nature, allow them to interact with hydrophobic surfaces and biological membranes.
Application
Pluronic® F-127 has been used:
- as a delivery system for a peptide to the wound site to study the effect of the peptide on wound healing in mice.
- as a surface coating for PDMS (polydimethylsiloxane) stamps to make them hydrogel repellent.
- in the preparation of calcium indicator stock solution for measuring neural activities.
- as a component of phosphate-buffered saline (PBS), to lower unspecific cell and protein adhesion to a PDMS-based microfluidic device.
- This non-ionic copolymer surfactant is suitable for use in insect cell culture applications as an antifoaming agent.
Biochem/physiol Actions
Pluronic® F-127 is a thermo-reversible gel that finds its application in different industries due to its high thermosensitivity, biodegradability, and biocompatibility properties. These properties make this polymer suitable for use as a versatile drug carrier.Pluronic® F-127 improves the therapeutic efficiency of drugs by increasing their bioavailability and thermostability. Additionally, it can promote cellular attachment and collagen formation, which facilitates angiogenesis and tissue regeneration. Due to its efficacy, Pluronic F-127 has been utilized in the encapsulation of mesenchymal stem cells (MSCs) to aid in the regeneration of tissues with low levels of vascularity, such as epithelial tissues, adipose tissues, cartilage, tendons, and bone tissues.
Legal Information
Pluronic is a registered trademark of BASF
저장 등급
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)