P7791
Prazosin hydrochloride
≥99.0% (HPLC), powder, α1-adrenoceptor antagonist
동의어(들):
1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine hydrochloride, Furazosin hydrochloride
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크기 선택
보기 변경
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C19H21N5O4 · HCl
CAS 번호:
Molecular Weight:
419.86
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
242-903-4
MDL number:
Beilstein/REAXYS Number:
4303561
Assay:
≥99.0% (HPLC)
Form:
powder
제품 이름
Prazosin hydrochloride, ≥99.0% (HPLC)
Quality Segment
assay
≥99.0% (HPLC)
form
powder
solubility
H2O: 0.5 mg/mL, methanol: 6 mg/mL, dilute aqueous acid: insoluble
SMILES string
Cl.COc1cc2nc(nc(N)c2cc1OC)N3CCN(CC3)C(=O)c4ccco4
InChI
1S/C19H21N5O4.ClH/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14;/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22);1H
InChI key
WFXFYZULCQKPIP-UHFFFAOYSA-N
Gene Information
human ... ADRA1A(148), ADRA1B(147), ADRA1D(146)
General description
Prazosin is a member of the class of α-adrenergic blockers. It is considered as a peripheral vasodilator antihypertensive agent. Prazosin is a derivative of quinazoline.
Application
Prazosin hydrochloride has been used:
- to block the α1adrenergic receptors that mediate sympathetic vasoconstriction in mice
- as an α1-adrenoceptor blocker,administered intragastrically in rats
- as a vasodilator,administered together with inuslin into the left ventricle of mice for the assessment of its effects on renal functions
Biochem/physiol Actions
Peripheral α1-adrenoceptor antagonist; vasodilator. Prazosin can be used to treat chronic posttraumatic stress disorder (PTSD). It plays a role in reducing blood pressure by relaxing blood vessels, hence used in the treatment of high blood pressure.
Features and Benefits
This compound is a featured product for ADME Tox and Neuroscience research. Discover more featured ADME Tox and Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the α1-Adrenoceptors, α2-Adrenoceptors and Melatonin Receptors pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
Disclaimer
Hygroscopic; light sensitive.
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signalword
Warning
hcodes
Hazard Classifications
Repr. 2 - STOT RE 2 - STOT SE 3
target_organs
Central nervous system
저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves