R0395
Rapamycin
from Streptomyces hygroscopicus, ≥95% (HPLC), powder, mTOR inhibitor
동의어(들):
23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine, AY 22989, Sirolimus
크기 선택
제품정보 (DICE 배송 시 비용 별도)
제품 이름
Rapamycin from Streptomyces hygroscopicus, ≥95% (HPLC), powder
Quality Segment
assay
≥95% (HPLC)
form
powder
color
off-white
solubility
ethanol: 2 mM, DMSO: soluble
antibiotic activity spectrum
fungi, yeast
mode of action
enzyme | inhibits, protein synthesis | interferes
storage temp.
−20°C
SMILES string
CO[C@@H]1C[C@@H](CC[C@H]1O)C[C@@H](C)[C@@H]2CC(=O)[C@H](C)\C=C(C)\[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)\C=C\C=C\C=C(C)\[C@H](C[C@@H]3CC[C@@H](C)[C@@](O)(O3)C(=O)C(=O)N4CCCC[C@H]4C(=O)O2)OC
InChI
1S/C51H79NO13/c1-30-16-12-11-13-17-31(2)42(61-8)28-38-21-19-36(7)51(60,65-38)48(57)49(58)52-23-15-14-18-39(52)50(59)64-43(33(4)26-37-20-22-40(53)44(27-37)62-9)29-41(54)32(3)25-35(6)46(56)47(63-10)45(55)34(5)24-30/h11-13,16-17,25,30,32-34,36-40,42-44,46-47,53,56,60H,14-15,18-24,26-29H2,1-10H3/b13-11+,16-12+,31-17+,35-25+/t30-,32-,33-,34-,36-,37+,38+,39+,40-,42+,43+,44-,46-,47+,51-/m1/s1
InChI key
QFJCIRLUMZQUOT-HPLJOQBZSA-N
Gene Information
human ... FKBP1A(2280)
General description
Application
- to treat BV2 cells or BV2-LC3 cells for autophagy assay
- as an autophagy activator in the bone marrow mesenchymal stem cells (BM-MSCs) transfected with lentivirus carrier of small interfering RNA for FOXO3 (siFOXO3) to study the effects of Forkhead Box O3 (FOXO3) on the autophagy of BM-MSCs
- to pre-incubate villi to inhibit the mammalian target of rapamycin complex 1 (mTORC1) signaling
Biochem/physiol Actions
Features and Benefits
Other Notes
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signalword
Warning
hcodes
Hazard Classifications
Carc. 2 - Repr. 2
저장 등급
11 - Combustible Solids
wgk
WGK 2
ppe
Eyeshields, Gloves, type N95 (US)