S0149
Streptolysin O from Streptococcus pyogenes
From Streptococcus pyogenes, Thiol-activated toxin, lyophilized powder
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제품정보 (DICE 배송 시 비용 별도)
Form:
lyophilized powder
제품 이름
Streptolysin O from Streptococcus pyogenes, γ-irradiated
biological source
Streptococcus pyogenes
Quality Segment
sterility
γ-irradiated
form
lyophilized powder
application(s)
cell analysis
storage temp.
2-8°C
Gene Information
Streptococcus pyogenes ... slo(900490)
Application
Streptolysin O from Streptococcus pyogenes has been used in streptolysin O (SLO) permeabilization. It has also been used to evaluate the barrier integrity and cytotoxicity of caco-2 and T84 IEC polarized monolayers.
Permeabilizes membranes to permit cellular uptake of large or charged molecules.
Biochem/physiol Actions
Streptolysin O (SLO), obtained from Streptococcus pyogenes has the capability to block osteoclastogenesis, induced by receptor activator of nuclear factor κ-Β ligand (RANK) through the NF-κB signaling pathway. Streptococcus pyogenes (GAS) is a bacterial strain that results in bacterial arthritis, osteomyelitis and implant infections.
Thiol-activated toxin that permeabilizes animal cell membranes. The protein binds as a monomer to membrane cholesterol and subsequently polymerizes into large arc- and ring-shaped structures surrounding pores of >12 nm.
Thiol-activated toxin that permeabilizes animal cell membranes..
Preparation Note
Prepared from S 5265
Other Notes
One unit will cause 50% lysis of 2% red blood cell suspensions in phosphate buffered saline, pH 7.4, after incubation at 37 °C for 30 min.
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signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 1 Dermal - Acute Tox. 1 Inhalation - Acute Tox. 1 Oral
저장 등급
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)